Gene-Map Pathway-Top10 Query Gene ID: vat    Query Name : Gid    Query Size(No. of Amino Acid) :
Pathway ID▼
Pathway
name
Score
Relaxed Genes
in Pathway
1st interacting Gene
in Pathway
2nd interacting Gene
in Pathway
*N1
All Genes
in Pathway
**N2
Biocarta id :
  53downstreampathway
Direct p53 effectors 2447.03
N/A
TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
RRM2B < TP53 < HDAC8
BBC3 < TP53 < HDAC8
TP53BP2 < Trp53 < Hdac8

TRIAP1 < TP53 < HDAC8
ZNF385A < TP53 < HDAC8
RPS27L < NFKBIA < HDAC8

S100A2 < TP53 < HDAC8
MSH2 < TP53 < HDAC8
HSPA1A < TP53 < HDAC8

PRMT1 < TP53 < HDAC8
PRMT1 < HIST2H4A < HDAC8
TP63 < TP53 < HDAC8

TP53INP1 < TP53 < HDAC8
DDX5 < TP53 < HDAC8
NFYA < TP53 < HDAC8

NFYB < TP53 < HDAC8
TNFRSF10B < TP53 < HDAC8
TAF9 < TP53 < HDAC8

ATF3 < TP53 < HDAC8
RCHY1 < TP53 < HDAC8
PLK3 < TP53 < HDAC8

NDRG1 < PRKACA < HDAC8
VDR < RUNX1T1 < HDAC8
SMARCA4 < Trp53 < Hdac8

SMARCA4 < TP53 < HDAC8
FOXA1 < HIST3H3 < HDAC8
GADD45A < HIST3H3 < HDAC8

HDAC2 < TP53 < HDAC8
RB1 < TP53 < HDAC8
MDM2 < HIST4H4 < HDAC8

MDM2 < TP53 < HDAC8
MDM2 < HIST3H3 < HDAC8
E2F1 < TP53 < HDAC8

BAX < TP53 < HDAC8
CAV1 < PRKACA < HDAC8
BCL2L1 < Trp53 < Hdac8

BCL2L1 < RTN1 < HDAC8
BCL2L1 < TP53 < HDAC8
CDKN1A < HIST4H4 < HDAC8

CDKN1A < TP53 < HDAC8
BCL2 < TP53 < HDAC8
SP1 < TP53 < HDAC8

CREBBP < TP53 < HDAC8
CREBBP < HIST3H3 < HDAC8
CREBBP < MDC1 < HDAC8

EP300 < HIST4H4 < HDAC8
EP300 < Trp53 < Hdac8
EP300 < TP53 < HDAC8

EP300 < MDC1 < HDAC8
98
CEBPZ
CDKN1A
NDRG1
PLK3

JMY
CREBBP
CSE1L
VCAN

CTSD
DDB2
GADD45A
DDX5

AFP
ARID3A
DUSP1
DUSP5

E2F1
E2F2
E2F3
EDN2

EGFR
EPHA2
EP300
FDXR

DKK1
PPP1R13B
RNF144B
RCHY1

ZNF385A
KAT2A
BBC3
SESN1

SFN
DPY19L4
GPX1
C13orf15

RNASEN
PYCARD
HTT
HDAC2

HGF
HIC1
FOXA1
APAF1

APC
PRMT1
HSPA1A
PPM1J

IGFBP3
FAS
IRF5
JUN

CD82
LIF
SH2D1A
MCL1

MDM2
MET
MLH1
MMP2

MSH2
ATF3
NFYA
NFYB

NFYC
RRM2B
SERPINE1
RPS27L

PCNA
TRIAP1
SERPINB5
PMAIP1

PML
PMS2
DGCR8
DDIT4

POU4F1
POU4F2
STEAP3
LRDD

PRKAB1
SCN3B
PCBP4
C12orf5

PTEN
BAK1
BAX
NLRC4

RB1
BCL2
BCL2A1
BCL2L1

BCL2L2
BCL6
BDKRB2
S100A2

BID
CX3CL1
PRDM1
PERP

RFWD2
SNAI2
SMARCA4
BNIP3L

SP1
SPP1
TAF9
TAP1

TFDP1
TGFA
TP53
TP53BP2

TP73
TSC2
TYRP1
VDR

BTG2
BCL2L14
COL18A1
TRRAP

CASP1
CASP6
CASP10
AIFM2

CAV1
TP63
TNFRSF10D
TNFRSF10C

TNFRSF10B
TNFRSF10A
CCNK
CCNB1

CCNG1
TADA2B
TP53INP1
MAP4K4

GDF15
TP53I3
138
PA164728156 Signaling events mediated by HDAC Class I - (Pathway
Interaction Database NCI-Nature Curated)
2100.00
HDAC8
NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

PRKACA < HDAC8
FKBP3 < TP53 < HDAC8
CHD3 < TP53 < HDAC8
SIN3A < TP53 < HDAC8

SIN3A < RUNX1T1 < HDAC8
NCOR1 < RUNX1T1 < HDAC8
NCOR1 < HIST4H4 < HDAC8

RBBP7 < HIST2H4A < HDAC8
HDAC3 < TP53 < HDAC8
HDAC3 < RUNX1T1 < HDAC8

HDAC3 < CBFA2T3 < HDAC8
HDAC3 < HIST4H4 < HDAC8
HDAC2 < TP53 < HDAC8

NCOR2 < NFKBIA < HDAC8
NCOR2 < RUNX1T1 < HDAC8
FBXW11 < NFKBIA < HDAC8

RBBP4 < HIST2H4A < HDAC8
UBE2I < TP53 < HDAC8
SUMO1 < TP53 < HDAC8

TNFRSF1A < HIST3H3 < HDAC8
HDAC1 < HIST4H4 < HDAC8
HDAC1 < TP53 < HDAC8

HDAC1 < RUNX1T1 < HDAC8
HDAC1 < CBFA2T3 < HDAC8
NFKB1 < NFKBIA < HDAC8

NFKB1 < TP53 < HDAC8
CREBBP < TP53 < HDAC8
CREBBP < HIST3H3 < HDAC8

CREBBP < MDC1 < HDAC8
RELA < NFKBIA < HDAC8
79
CHD3
CHD4
CREBBP
FBXW11

FKBP3
GATA1
GATA2
GATAD2A

GATAD2B
HDAC1
HDAC2
HDAC3

HDAC8
MAX
MBD2
MBD3

MBD3L2
MTA2
MXD1
NCOR1

NCOR2
NFKB1
NFKBIA
NR2C1

NUP153
NUP210
NUP214
NUP62

PPARG
PRKACA
PRMT5
RAN

RANBP2
RANGAP1
RBBP4
RBBP7

RELA
SAP18
SAP30
SIN3A

SIN3B
SMAD7
SMG5
SMURF1

STAT3
SUMO1
TFCP2
TNF

TNFRSF1A
UBE2I
WDR77
XPO1

YY1
ZFPM1
54
PA164728170 p75(NTR)-mediated signaling - (Pathway Interaction
Database NCI-Nature Curated)
1630.00
N/A
TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
TP53 < HDAC8

TP53 < HDAC8
RTN4 < RTN1 < HDAC8
MAPK9 < TP53 < HDAC8
E2F1 < TP53 < HDAC8

IKBKB < NFKBIA < HDAC8
BAD < PRKACA < HDAC8
IKBKG < NFKBIA < HDAC8

CHUK < NFKBIA < HDAC8
CHUK < HIST3H3 < HDAC8
57
ADAM17
AKT1
APAF1
APH1A

APH1B
APP
ARHGDIA
BAD

BCL2L11
BDNF
BEX1
CASP3

CASP6
CASP9
CHUK
CYCS

DIABLO
E2F1
FURIN
IKBKB

IKBKG
IRAK1
MAGED1
MAGEH1

MAPK9
MMP3
MMP7
MYD88

NCSTN
NDN
NDNL2
NGF

NGFR
NGFRAP1
NTF3
NTF4

NTRK1
PIK3CA
PIK3R1
PLG

PRDM4
PRKACB
PRKCZ
PSEN1

PSENEN
RAC1
RHOA
RHOB

RIPK2
RTN4
RTN4R
SHC1

SMPD2
SORT1
SQSTM1
TP53

TRAF6
XIAP
YWHAE
ZNF274
60
KEGG Pathway :
  go04113
Meiosis - yeast 1580.55
N/A
AGOS_AEL292W < AGOS_AGR395W
AGOS_AEL230W < AGOS_AGR395W

AGOS_AFR166C < AGOS_AGR395W
AGOS_AGL099C < AGOS_AGR395W

AGOS_AGL099C < AGOS_AGR395W
AGOS_AGL099C < AGOS_AGR395W

AGOS_AGL099C < AGOS_AGR395W
AGOS_AGL099C < AGOS_AGR395W

AGOS_AGL099C < AGOS_AGR395W
AGOS_AGL099C < AGOS_AGR395W

AGOS_AGL099C < AGOS_AGR395W
AGOS_AGL099C < AGOS_AGR395W

AGOS_AGL099C < AGOS_AGR395W
AGOS_AGL099C < AGOS_AGR395W

AGOS_AGL099C < AGOS_AGR395W
AGOS_AGL099C < AGOS_AGR395W

AGOS_AGL099C < AGOS_AGR395W
AGOS_AGL099C < AGOS_AGR395W

AGOS_AGL099C < AGOS_AGR395W
AGOS_AGL099C < AGOS_AGR395W

AGOS_AGL099C < AGOS_AGR395W
AGOS_AGL099C < AGOS_AGR395W

AGOS_AGL099C < AGOS_AGR395W
AGOS_AGL099C < AGOS_AGR395W

AGOS_AGL099C < AGOS_AGR395W
AGOS_AGL099C < AGOS_AGR395W

AGOS_AGL099C < AGOS_AGR395W
AGOS_AGL099C < AGOS_AGR395W

AGOS_AGL099C < AGOS_AGR395W
AGOS_AGL099C < AGOS_AGR395W

AGOS_AGL099C < AGOS_AGR395W
AGOS_AGL099C < AGOS_AGR395W

AGOS_AGL099C < AGOS_AGR395W
AGOS_AGL099C < AGOS_AGR395W

AGOS_AGL099C < AGOS_AGR395W
AGOS_AGL099C < AGOS_AGR395W

AGOS_AGL099C < AGOS_AGR395W
AGOS_AGL099C < AGOS_AGR395W

AGOS_AGL099C < AGOS_AGR395W
AGOS_AGL099C < AGOS_AGR395W

AGOS_AGL099C < AGOS_AGR395W
AGOS_AGL099C < AGOS_AGR395W

AGOS_AGL099C < AGOS_AGR395W
AGOS_AGL099C < AGOS_AGR395W

AGOS_AGL099C < AGOS_AGR395W
AGOS_AGL099C < AGOS_AGR395W

AGOS_AGL099C < AGOS_AGR395W
AGOS_AGL099C < AGOS_AGR395W

AGOS_AGL099C < AGOS_AGR395W
AGOS_AGL099C < AGOS_AGR395W

AGOS_AGL099C < AGOS_AGR395W
AGOS_AGL099C < AGOS_AGR395W

AGOS_AGL099C < AGOS_AGR395W
AGOS_AGL099C < AGOS_AGR395W

AGOS_AGL099C < AGOS_AGR395W
AGOS_AGL099C < AGOS_AGR395W

AGOS_AFL065C < AGOS_AGR395W
AGOS_AGR071C < AGOS_AGR395W

AGOS_AGR071C < AGOS_AGR395W
AGOS_AGR071C < AGOS_AGR395W

AGOS_AGR071C < AGOS_AGR395W
AGOS_AGR071C < AGOS_AGR395W

AGOS_AGR071C < AGOS_AGR395W
AGOS_AGR071C < AGOS_AGR395W

AGOS_AGR071C < AGOS_AGR395W
AGOS_AGR071C < AGOS_AGR395W

AGOS_AGR071C < AGOS_AGR395W
AGOS_AGR071C < AGOS_AGR395W

AGOS_AGR071C < AGOS_AGR395W
AGOS_AGR071C < AGOS_AGR395W

AGOS_AGR071C < AGOS_AGR395W
AGOS_AGR071C < AGOS_AGR395W

AGOS_AGR071C < AGOS_AGR395W
AGOS_AGR071C < AGOS_AGR395W

AGOS_AGR071C < AGOS_AGR395W
AGOS_AGR071C < AGOS_AGR395W

AGOS_AGR071C < AGOS_AGR395W
AGOS_AGR071C < AGOS_AGR395W

AGOS_AGR071C < AGOS_AGR395W
AGOS_AGR071C < AGOS_AGR395W

AGOS_AGR071C < AGOS_AGR395W
AGOS_AGR071C < AGOS_AGR395W

AGOS_AGR071C < AGOS_AGR395W
AGOS_AGR071C < AGOS_AGR395W

AGOS_AGR071C < AGOS_AGR395W
AGOS_AGR071C < AGOS_AGR395W

AGOS_AGR071C < AGOS_AGR395W
AGOS_AGR071C < AGOS_AGR395W

AGOS_AGR071C < AGOS_AGR395W
AGOS_AGR071C < AGOS_AGR395W

AGOS_AGR071C < AGOS_AGR395W
AGOS_AGR071C < AGOS_AGR395W

AGOS_AGR071C < AGOS_AGR395W
AGOS_AGR071C < AGOS_AGR395W

AGOS_AGR071C < AGOS_AGR395W
AGOS_AGR071C < AGOS_AGR395W

AGOS_AGR071C < AGOS_AGR395W
AGOS_AGR071C < AGOS_AGR395W

AGOS_AGR071C < AGOS_AGR395W
AGOS_AGR071C < AGOS_AGR395W

AGOS_AGR071C < AGOS_AGR395W
AGOS_AGR071C < AGOS_AGR395W

AGOS_AGR071C < AGOS_AGR395W
AGOS_AGR071C < AGOS_AGR395W

AGOS_AGR071C < AGOS_AGR395W
AGOS_AGR071C < AGOS_AGR395W

AGOS_AGR071C < AGOS_AGR395W
AGOS_AGR071C < AGOS_AGR395W

AGOS_AGR071C < AGOS_AGR395W
AGOS_AGR071C < AGOS_AGR395W

AGOS_AEL149C < AGOS_AGR395W
AGOS_AEL025W < AGOS_AGR395W

AGOS_ABR108C < AGOS_AGR395W
AGOS_AFL014C < AGOS_AGR395W

AGOS_AGL297C < AGOS_AGR395W
AGOS_ACR168W < AGOS_AGR395W

AGOS_AFR690C < AGOS_AGR395W
N/A
117
AGOS_AAL045C
AGOS_AAL085C
AGOS_AAL094W
AGOS_AAL162C

AGOS_AAL169C
AGOS_AAL182W
AGOS_AAR089C
AGOS_AAR100C

AGOS_ABR055C
AGOS_ABR089C
AGOS_ABR108C
AGOS_ABR127C

AGOS_ABR135C
AGOS_ABR178C
AGOS_ABR206W
AGOS_ABR240W

AGOS_ACL006W
AGOS_ACL029W
AGOS_ACR043W
AGOS_ACR142W

AGOS_ACR168W
AGOS_ACR218W
AGOS_ACR279C
AGOS_ADL026W

AGOS_ADL093W
AGOS_ADL135C
AGOS_ADR025W
AGOS_ADR041W

AGOS_ADR058C
AGOS_ADR068W
AGOS_ADR091W
AGOS_ADR099C

AGOS_ADR218W
AGOS_ADR253W
AGOS_ADR379C
AGOS_ADR411W

AGOS_AEL025W
AGOS_AEL089C
AGOS_AEL115C
AGOS_AEL149C

AGOS_AEL185C
AGOS_AEL221C
AGOS_AEL230W
AGOS_AEL292W

AGOS_AEL333W
AGOS_AER016C
AGOS_AER133C
AGOS_AER216C

AGOS_AER223C
AGOS_AFL014C
AGOS_AFL065C
AGOS_AFL075W

AGOS_AFL090W
AGOS_AFL174C
AGOS_AFL204C
AGOS_AFL205C

AGOS_AFL207C
AGOS_AFR021W
AGOS_AFR076W
AGOS_AFR130W

AGOS_AFR166C
AGOS_AFR178W
AGOS_AFR272W
AGOS_AFR353W

AGOS_AFR355C
AGOS_AFR546W
AGOS_AFR571W
AGOS_AFR621C

AGOS_AFR656C
AGOS_AFR690C
AGOS_AFR724C
AGOS_AGL023W

AGOS_AGL099C
AGOS_AGL193W
AGOS_AGL205C
AGOS_AGL294W

AGOS_AGL297C
AGOS_AGL304W
AGOS_AGR028C
AGOS_AGR070C

AGOS_AGR071C
AGOS_AGR083W
AGOS_AGR101C
AGOS_AGR112C

AGOS_AGR173C
AGOS_AGR229W
AGOS_AGR260W
AGOS_AGR276W

AGOS_AGR289C
AGOS_AGR315C
AGOS_AGR347W
91
Biocarta id :
  crpathway
t cell receptor signaling pathway 1559.26
N/A
NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8

NFKBIA < HDAC8
NFKBIA < HDAC8
PTPN7 < PRKACA < HDAC8
FOS < PRKACA < HDAC8
RELA < NFKBIA < HDAC8

MAPK8 < Trp53 < Hdac8
MAPK8 < TP53 < HDAC8
GRB2 < HIST2H4A < HDAC8
54
RALBP1
CHN1
ARAP2
ARAP1

ELK1
FOS
FYN
ARFGAP3

LAT
GRB2
HLA-DRA
HLA-DRB1

HRAS
JUN
ARHGAP1
ARHGAP4

LCK
ARHGAP5
ARHGAP6
MAP3K1

NCF2
NFATC1
NFKBIA
ASAP1

PIK3CA
PIK3R1
PLCG1
PPP3CA

PPP3CB
PPP3CC
ARFGAP1
PRKCA

PRKCB
MAPK3
MAPK8
MAP2K1

PTPN7
PTPRC
RAC1
RAF1

RELA
MAP2K4
SHC1
SOS1

TRA@
TRB@
VAV1
ZAP70

CAMK2B
ASAP2
CD3D
CD3E

CD3G
CD247
CD4
55
Biocarta id :
  mad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling 818.52
N/A
N/A
HSPA8 < TP53 < HDAC8
TCF3 < RUNX1T1 < HDAC8
TCF3 < CBFA2T3 < HDAC8

ATF3 < TP53 < HDAC8
HNF4A < TP53 < HDAC8
E2F4 < HIST2H4A < HDAC8

VDR < RUNX1T1 < HDAC8
RBBP7 < HIST2H4A < HDAC8
PIAS4 < Trp53 < Hdac8

NR3C1 < PRKACA < HDAC8
NR3C1 < TP53 < HDAC8
SMAD2 < TP53 < HDAC8

SIN3A < TP53 < HDAC8
SIN3A < RUNX1T1 < HDAC8
NCOR1 < RUNX1T1 < HDAC8

NCOR1 < HIST4H4 < HDAC8
RBBP4 < HIST2H4A < HDAC8
HDAC2 < TP53 < HDAC8

AR < TP53 < HDAC8
SMAD3 < TP53 < HDAC8
KAT2B < TP53 < HDAC8

ESR1 < PRKACA < HDAC8
CDK2 < TP53 < HDAC8
FOXO3 < TP53 < HDAC8

CDKN1A < HIST4H4 < HDAC8
CDKN1A < TP53 < HDAC8
SP1 < TP53 < HDAC8

HDAC1 < HIST4H4 < HDAC8
HDAC1 < TP53 < HDAC8
HDAC1 < RUNX1T1 < HDAC8

HDAC1 < CBFA2T3 < HDAC8
CREB1 < PRKACA < HDAC8
CREB1 < TP53 < HDAC8

CREBBP < TP53 < HDAC8
CREBBP < HIST3H3 < HDAC8
CREBBP < MDC1 < HDAC8

EP300 < HIST4H4 < HDAC8
EP300 < Trp53 < Hdac8
EP300 < TP53 < HDAC8

EP300 < MDC1 < HDAC8
FOS < PRKACA < HDAC8
41
CDK2
CDK4
CDKN1A
SAP18

CDKN2B
PIAS3
NCOA2
CEBPB

COL1A2
CREB1
ATF2
CREBBP

GSC
NKX2-5
CTBP1
DLX1

E2F4
E2F5
EP300
AKT1

ESR1
FOXG1
FOXO1
FOXO3

SIN3B
FOS
SIN3A
GATA3

KAT2A
NR3C1
HDAC1
HDAC2

HNF4A
HSPA8
IFNB1
IL5

IL10
IRF7
AR
ITGB5

JUN
LAMC1
SMAD2
SMAD3

SMAD4
SMAD7
MAX
MEF2C

FOXO4
CITED1
MYC
MYOD1

ATF3
SERPINE1
MED15
PIAS4

DCP1A
RBBP4
RBBP7
RBL1

TGIF2
SKI
SKIL
SP1

SP3
TCF3
TFDP1
TFE3

TGIF1
VDR
ZBTB17
SNIP1

RUNX2
RUNX1
RUNX3
NCOA1

CBFB
SAP30
KAT2B
FOXH1

NCOR1
81
Biocarta id :
  apkpathway
mapkinase signaling pathway 298.52
N/A
N/A
MAPK9 < TP53 < HDAC8
MAPK10 < Trp53 < Hdac8
MAPK10 < TP53 < HDAC8

MAP3K3 < NFKBIA < HDAC8
MAP3K14 < NFKBIA < HDAC8
SP1 < TP53 < HDAC8

RPS6KA1 < NFKBIA < HDAC8
IKBKB < NFKBIA < HDAC8
CREB1 < PRKACA < HDAC8

CREB1 < TP53 < HDAC8
CHUK < NFKBIA < HDAC8
CHUK < HIST3H3 < HDAC8

FOS < PRKACA < HDAC8
MAPK8 < Trp53 < Hdac8
MAPK8 < TP53 < HDAC8
15
CEBPA
MAP3K2
MAP4K5
MAP4K1

CHUK
MAP3K8
CREB1
ATF2

MAPK14
ELK1
FOS
GCK

HRAS
IKBKB
ARAF
JUN

MAX
MEF2A
LOC729991-MEF2B
MEF2C

MEF2D
MAP3K1
MAP3K3
MAP3K4

MAP3K5
MAP3K11
MYC
PAK1

PAK2
MAPK1
MAPK3
MAPK7

MAPK8
MAPK11
MAPK9
MAPK10

MAPK13
MAP2K1
MAP2K2
MAP2K3

MAP2K5
MAP2K6
MAP2K7
RAC1

RAF1
RPS6KA1
MAPK12
MAP2K4

SP1
STAT1
MAP3K7
MAP3K12

MAP4K3
MAP3K14
MAP3K13
MAP4K4
56
PA164713444 mapkinase signaling pathway - (BioCarta via Pathway
Interaction Database)
219.26
N/A
N/A
MAPK10 < Trp53 < Hdac8
MAPK10 < TP53 < HDAC8
MAP3K14 < NFKBIA < HDAC8

RPS6KA1 < NFKBIA < HDAC8
SP1 < TP53 < HDAC8
IKBKB < NFKBIA < HDAC8

CHUK < NFKBIA < HDAC8
CHUK < HIST3H3 < HDAC8
CREB1 < PRKACA < HDAC8

CREB1 < TP53 < HDAC8
FOS < PRKACA < HDAC8
11
ARAF
ATF2
CEBPA
CHUK

CREB1
ELK1
FOS
HRAS

IKBKB
JUN
MAP2K1
MAP2K2

MAP2K3
MAP2K4
MAP2K5
MAP2K6

MAP2K7
MAP3K1
MAP3K13
MAP3K14

MAP3K4
MAP3K5
MAP3K7
MAP3K8

MAP4K3
MAP4K5
MAPK10
MAPK11

MAPK14
MAPK3
MAPK7
MAX

MEF2B
MYC
PAK1
PAK2

RAC1
RPS6KA1
SP1
STAT1
40
PA164728161 Signaling events activated by Hepatocyte Growth Factor
Receptor (c-Met) - (Pathway Interaction Database NCI-Nature Curated)
199.26
N/A
N/A
RAP1B < PRKACA < HDAC8
BAG1 < TP53 < HDAC8
BAD < PRKACA < HDAC8

PTK2 < TP53 < HDAC8
FOS < PRKACA < HDAC8
MAPK8 < Trp53 < Hdac8

MAPK8 < TP53 < HDAC8
SRC < NFKBIA < HDAC8
SRC < PRKACA < HDAC8

GRB2 < HIST2H4A < HDAC8
10
AKT1
BAD
BAG1
CBL

CRK
CRKL
CTNNB1
DOCK1

ELK1
FOS
GAB1
GLMN

GRB2
HGF
HGS
HRAS

INPPL1
JUN
MAP2K1
MAP2K2

MAP2K4
MAP3K5
MAP4K1
MAPK1

MAPK3
MAPK8
MET
MUC20

NCK1
PAK1
PDPK1
PIK3CA

PIK3R1
PLCG1
PTEN
PTK2

PTK2B
PTPN11
PTPRJ
PXN

RAF1
RANBP10
RANBP9
RAP1A

RAP1B
RAPGEF1
RASA1
RPS6KB1

SH3KBP1
SHC1
SOS1
SRC

STAT3
53
Biocarta id :
  tp1bpathway
Signaling events mediated by PTP1B 180.00
N/A
N/A
YBX1 < TP53 < HDAC8
CAPN1 < TP53 < HDAC8
CSK < PRKACA < HDAC8

PTPN1 < NFKBIA < HDAC8
CAV1 < PRKACA < HDAC8
JAK2 < NFKBIA < HDAC8

GRB2 < HIST2H4A < HDAC8
SRC < NFKBIA < HDAC8
SRC < PRKACA < HDAC8
9
CDH2
SPRY2
CRK
CSF1

CSF1R
CSK
CSN2
DOK1

EGF
EGFR
AKT1
FCGR2A

FER
FGR
FYN
LAT

GRB2
HCK
INS
INSR

IRS1
ITGA2B
ITGB3
JAK2

RHOA
LCK
LEP
LEPR

LYN
YBX1
NOX4
PDGFRB

PIK3CA
PIK3R1
TRPV6
PRL

PRLR
PTPN1
BLK
SHC1

SRC
STAT3
STAT5A
STAT5B

TXN
TYK2
YES1
CAPN1

CAV1
SOCS3
BCAR1
51
Biocarta id :
  nsulin_glucose_pathway
Insulin-mediated glucose transport 140.00
N/A
N/A
GYS1 < PRKACA < HDAC8
PPP1CC < TP53 < HDAC8
YWHAG < TP53 < HDAC8

YWHAZ < TP53 < HDAC8
CALM3 < NFKBIA < HDAC8
GSK3B < PRKACA < HDAC8

GSK3B < TP53 < HDAC8
7
YWHAQ
AKT1
AKT2
RHOQ

STXBP4
SFN
GSK3B
GYS1

INS
INSR
LNPEP
ASIP

PPP1CC
PPP1R3A
PRKCI
PRKCZ

SLC2A4
STX4
VAMP2
YWHAB

YWHAE
YWHAG
YWHAH
YWHAZ

CALM3
TRIP10
TBC1D4
27
Biocarta id :
  aspathway
fas signaling pathway (cd95) 139.26
N/A
N/A
PTPN13 < NFKBIA < HDAC8
PRKDC < TP53 < HDAC8
PRKDC < MDC1 < HDAC8

DAXX < TP53 < HDAC8
DAXX < HIST4H4 < HDAC8
MAPK8 < Trp53 < Hdac8

MAPK8 < TP53 < HDAC8
7
FAF1
DAXX
FAS
FASLG

MAP3K1
PAK1
PAK2
PRKDC

MAPK8
PTPN13
MAP2K4
MAP3K7

CASP3
CASP7
CASP8
CASP10

RIPK2
FADD
CFLAR
19
PA164713452 erk1/erk2 mapk signaling pathway - (BioCarta via Pathway
Interaction Database)
120.00
N/A
N/A
PTPRR < PRKACA < HDAC8
RPS6KA5 < HIST3H3 < HDAC8
RPS6KA1 < NFKBIA < HDAC8

SRC < NFKBIA < HDAC8
SRC < PRKACA < HDAC8
GRB2 < HIST2H4A < HDAC8
6
ELK1
GRB2
HRAS
MAP2K1

MAP2K2
MAPK1
MAPK3
MKNK1

MKNK2
MYC
NGF
NGFR

PPP2R5D
PTPRR
RAF1
RPS6KA1

RPS6KA5
SHC1
SOS1
SRC

STAT3
TERT
22
Biocarta id :
  phbfwdpathway
EPHB forward signaling 120.00
N/A
N/A
GRIA1 < PRKACA < HDAC8
RAP1B < PRKACA < HDAC8
PTK2 < TP53 < HDAC8

GRB2 < HIST2H4A < HDAC8
SRC < NFKBIA < HDAC8
SRC < PRKACA < HDAC8
6
CRK
DNM1
EFNA5
EFNB1

EFNB2
EFNB3
EPHB1
EPHB2

EPHB3
EPHB4
GRB2
GRB7

GRIA1
HRAS
KRAS
NCK1

NRAS
PAK1
PIK3CA
PIK3R1

MAPK1
MAPK3
MAP2K1
PTK2

PXN
RAC1
RAP1A
RAP1B

RASA1
ROCK1
RRAS
ITSN1

SHC1
SRC
TF
SYNJ1

WASL
KALRN
MAP4K4
CDC42
40
Reactome id :
  63
Packaging Of Telomere Ends - (Reactome via Pathway
Interaction Database)
110.00
N/A
HIST2H4A < HDAC8
HIST3H3 < HDAC8

HIST4H4 < HDAC8
TERF2IP < MDC1 < HDAC8
4
ACD
HIST1H4A
HIST1H4B
HIST1H4C

HIST1H4D
HIST1H4E
HIST1H4F
HIST1H4H

HIST1H4I
HIST1H4J
HIST1H4K
HIST1H4L

HIST2H4A
HIST3H3
HIST4H4
POT1

TERF1
TERF2
TERF2IP
TINF2
20
KEGG Pathway :
  go03010
Ribosome 94.56
N/A
AGOS_AEL137W < AGOS_AGR395W
AGOS_ADR095W < AGOS_AGR395W

AGOS_ADL391C < AGOS_AGR395W
AGOS_ACR221W < AGOS_AGR395W

AGOS_ABR033C < AGOS_AGR395W
AGOS_ACL070C < AGOS_AGR395W

AGOS_ACR120C < AGOS_AGR395W
N/A
7
AGOS_AAL011C
AGOS_AAR027W
AGOS_AAR108C
AGOS_AAR134W

AGOS_AAR177W
AGOS_AAR191C
AGOS_ABL091C
AGOS_ABL138W

AGOS_ABR005C
AGOS_ABR010C
AGOS_ABR033C
AGOS_ABR041C

AGOS_ABR148W
AGOS_ABR171W
AGOS_ABR235W
AGOS_ACL043W

AGOS_ACL070C
AGOS_ACL076W
AGOS_ACL140C
AGOS_ACL178C

AGOS_ACL184C
AGOS_ACR065C
AGOS_ACR104C
AGOS_ACR120C

AGOS_ACR221W
AGOS_ACR255C
AGOS_ADL078C
AGOS_ADL125C

AGOS_ADL127C
AGOS_ADL157C
AGOS_ADL158C
AGOS_ADL166W

AGOS_ADL290W
AGOS_ADL391C
AGOS_ADR095W
AGOS_ADR103C

AGOS_ADR206W
AGOS_ADR256W
AGOS_ADR257C
AGOS_ADR258W

AGOS_ADR346W
AGOS_ADR412C
AGOS_AEL137W
AGOS_AEL150W

AGOS_AEL152W
AGOS_AEL254W
AGOS_AEL255W
AGOS_AEL325W

AGOS_AEL342W
AGOS_AEL343C
AGOS_AER052W
AGOS_AER076C

AGOS_AER131C
AGOS_AER149W
AGOS_AER179C
AGOS_AER315C

AGOS_AER319W
AGOS_AER367C
AGOS_AER422C
AGOS_AFL035C

AGOS_AFL082W
AGOS_AFL116W
AGOS_AFL163C
AGOS_AFR034W

AGOS_AFR145C
AGOS_AFR163C
AGOS_AFR194W
AGOS_AFR214C

AGOS_AFR285C
AGOS_AFR403W
AGOS_AFR413C
AGOS_AFR477C

AGOS_AFR478W
AGOS_AFR501C
AGOS_AFR569W
AGOS_AFR688C

AGOS_AGL030W
AGOS_AGL128W
AGOS_AGL281C
AGOS_AGL288W

AGOS_AGL310C
AGOS_AGR197C
AGOS_AGR261W
AGOS_AGR287C

AGOS_AGR375W
85
Reactome id :
  364
DARPP-32 events - (Reactome via Pathway Interaction
Database)
90.00
N/A
PRKACA < HDAC8
PPP1CA < TP53 < HDAC8
PPP1R1B < PRKACA < HDAC8
CALM3 < NFKBIA < HDAC8
4
CALM1
CALM2
CALM3
CDK5

PDE4B
PPP1CA
PPP1R1B
PPP3R1

PRKACA
9
KEGG Pathway :
  go00310
Lysine degradation 40.53
N/A
AGOS_AEL128C < AGOS_AGR395W
AGOS_AER326C < AGOS_AGR395W

AGOS_ABR136W < AGOS_AGR395W
N/A
3
AGOS_ABR116C
AGOS_ABR136W
AGOS_ACL028W
AGOS_ACL044W

AGOS_ACR167C
AGOS_ADL346W
AGOS_ADR165C
AGOS_ADR417W

AGOS_AEL035W
AGOS_AEL128C
AGOS_AER326C
AGOS_AER374C

AGOS_AGL200W
AGOS_AGR382W
14
Reactome id :
  77
Mitotic Prometaphase - (Reactome via Pathway Interaction
Database)
40.00
N/A
N/A
PPP1CC < TP53 < HDAC8
PLK1 < TP53 < HDAC8
2
AHCTF1
APITD1
AURKB
B9D2

BIRC5
BUB1
BUB1B
BUB3

CASC5
CCDC99
CDC20
CDCA8

CENPA
CENPC1
CENPE
CENPF

CENPH
CENPI
CENPK
CENPL

CENPM
CENPN
CENPO
CENPP

CENPQ
CENPT
CKAP5
CLASP1

CLASP2
CLIP1
DSN1
ERCC6L

INCENP
ITGB3BP
KIF18A
KIF2A

KIF2B
KIF2C
KNTC1
MAD1L1

MAD2L1
MAPRE1
MIS12
MLF1IP

NDC80
NDE1
NDEL1
NSL1

NUDC
NUF2
NUP107
NUP133

NUP160
NUP37
NUP43
NUP85

NUP98
PAFAH1B1
PLK1
PPP1CC

RAD21
RANBP2
RANGAP1
RCC2

REC8
RPS27
SEC13
SEC13

SEH1L
SGOL1
SGOL2
SMC1A

SMC3
SPC24
SPC25
STAG1

STAG2
TAOK1
XPO1
ZW10

ZWILCH
ZWINT
82
Reactome id :
  217
RNA Polymerase III Transcription Initiation From Type
3 Promoter - (Reactome via Pathway Interaction Database)
40.00
N/A
N/A
POU2F1 < PRKACA < HDAC8
TBP < TP53 < HDAC8
2
BRF2
LZTS1
POLR2E
POLR2F

POLR2H
POLR2K
POLR2L
POLR3A

POLR3B
POLR3D
POLR3E
POLR3F

POLR3H
POU2F1
SNAPC1
SNAPC2

SNAPC3
SNAPC4
SNAPC5
TBP

ZNF143
21
Biocarta id :
  rionpathway
prion pathway 40.00
N/A
N/A
HSPA5 < TP53 < HDAC8
BCL2 < TP53 < HDAC8
2
DNAJB6
LAMC3
DNAJB1P1
GFAP

LAMA1
HSPA5
LAMA2
LAMA3

LAMA4
LAMA5
LAMB1
LAMB2

LAMB3
LAMC1
LAMC2
RPSA

PRNP
BCL2
18
KEGG Pathway :
  go00051
Fructose and mannose metabolism 27.02
N/A
AGOS_AEL106W < AGOS_AGR395W
AGOS_AFR279C < AGOS_AGR395W
N/A
2
AGOS_ABR068C
AGOS_ABR229C
AGOS_ABR236W
AGOS_ADL183C

AGOS_ADL237C
AGOS_ADR003C
AGOS_AEL106W
AGOS_AEL208W

AGOS_AER401W
AGOS_AFL185W
AGOS_AFR279C
AGOS_AFR593C

AGOS_AFR599W
AGOS_AFR716C
AGOS_AGL060W
AGOS_AGL201C
16
*Total number of Query Gene in Pathway     **Total number of Genes in Pathway