Gene-Map Pathway-Top10 Query Gene ID: vat    Query Name : Gid    Query Size(No. of Amino Acid) :
Pathway ID▼
Pathway
name
Score
Relaxed Genes
in Pathway
1st interacting Gene
in Pathway
2nd interacting Gene
in Pathway
*N1
All Genes
in Pathway
**N2
PA164714014 Integrin cell surface interactions - (Reactome via
Pathway Interaction Database)
420.00
N/A
VTN < ANGPTL4
FN1 < ANGPTL4
ITGB8 < VTN < ANGPTL4
ITGB6 < VTN < ANGPTL4
COL2A1 < FN1 < ANGPTL4

THBS1 < FN1 < ANGPTL4
THBS1 < VTN < ANGPTL4
ITGB5 < VTN < ANGPTL4

ITGA3 < FN1 < ANGPTL4
SPP1 < FN1 < ANGPTL4
PECAM1 < FN1 < ANGPTL4

ITGA5 < FN1 < ANGPTL4
ITGA4 < FN1 < ANGPTL4
FGG < VTN < ANGPTL4

ITGAV < FN1 < ANGPTL4
ITGAV < VTN < ANGPTL4
COL1A1 < FN1 < ANGPTL4

COL1A2 < FN1 < ANGPTL4
ITGB3 < VTN < ANGPTL4
ITGB1 < FN1 < ANGPTL4
20
AMICA1
BSG
CDH1
COL1A1

COL1A2
COL2A1
F11R
FBN1

FGA
FGB
FGG
FN1

IBSP
ITGA1
ITGA10
ITGA11

ITGA2
ITGA2B
ITGA3
ITGA4

ITGA5
ITGA6
ITGA7
ITGA8

ITGA9
ITGAD
ITGAE
ITGAL

ITGAM
ITGAV
ITGAX
ITGB1

ITGB2
ITGB3
ITGB4
ITGB5

ITGB6
ITGB7
ITGB8
JAM2

JAM3
LAMA1
LAMA2
LAMA5

LAMB1
LAMB2
LAMC1
LAMC3

MADCAM1
PECAM1
SPP1
THBS1

TNC
VCAM1
VTN
55
Biocarta id :
  53downstreampathway
Direct p53 effectors 275.08
N/A
N/A
DDX5 < FN1 < ANGPTL4
IGFBP3 < FN1 < ANGPTL4
RFWD2 < FOXO1 < ANGPTL4

CTSD < FN1 < ANGPTL4
SPP1 < FN1 < ANGPTL4
TSC2 < FOXO1 < ANGPTL4

SERPINE1 < VTN < ANGPTL4
GADD45A < Ppara < Angptl4
CCNB1 < FOXO1 < ANGPTL4

HGF < VTN < ANGPTL4
CDKN1A < FOXO1 < ANGPTL4
CREBBP < FOXO1 < ANGPTL4

CREBBP < PPARA < ANGPTL4
EP300 < PPARA < ANGPTL4
14
CEBPZ
CDKN1A
NDRG1
PLK3

JMY
CREBBP
CSE1L
VCAN

CTSD
DDB2
GADD45A
DDX5

AFP
ARID3A
DUSP1
DUSP5

E2F1
E2F2
E2F3
EDN2

EGFR
EPHA2
EP300
FDXR

DKK1
PPP1R13B
RNF144B
RCHY1

ZNF385A
KAT2A
BBC3
SESN1

SFN
DPY19L4
GPX1
C13orf15

RNASEN
PYCARD
HTT
HDAC2

HGF
HIC1
FOXA1
APAF1

APC
PRMT1
HSPA1A
PPM1J

IGFBP3
FAS
IRF5
JUN

CD82
LIF
SH2D1A
MCL1

MDM2
MET
MLH1
MMP2

MSH2
ATF3
NFYA
NFYB

NFYC
RRM2B
SERPINE1
RPS27L

PCNA
TRIAP1
SERPINB5
PMAIP1

PML
PMS2
DGCR8
DDIT4

POU4F1
POU4F2
STEAP3
LRDD

PRKAB1
SCN3B
PCBP4
C12orf5

PTEN
BAK1
BAX
NLRC4

RB1
BCL2
BCL2A1
BCL2L1

BCL2L2
BCL6
BDKRB2
S100A2

BID
CX3CL1
PRDM1
PERP

RFWD2
SNAI2
SMARCA4
BNIP3L

SP1
SPP1
TAF9
TAP1

TFDP1
TGFA
TP53
TP53BP2

TP73
TSC2
TYRP1
VDR

BTG2
BCL2L14
COL18A1
TRRAP

CASP1
CASP6
CASP10
AIFM2

CAV1
TP63
TNFRSF10D
TNFRSF10C

TNFRSF10B
TNFRSF10A
CCNK
CCNB1

CCNG1
TADA2B
TP53INP1
MAP4K4

GDF15
TP53I3
138
PA164714347 Exocytosis of Alpha granule - (Reactome via Pathway
Interaction Database)
270.00
N/A
FN1 < ANGPTL4
SPARC < FN1 < ANGPTL4
ALB < FN1 < ANGPTL4
CD36 < FN1 < ANGPTL4

PECAM1 < FN1 < ANGPTL4
SERPINE1 < VTN < ANGPTL4
HGF < VTN < ANGPTL4

FGG < VTN < ANGPTL4
PLG < FN1 < ANGPTL4
KNG1 < VTN < ANGPTL4

IGF1 < FN1 < ANGPTL4
IGF1 < VTN < ANGPTL4
ITGB3 < VTN < ANGPTL4
13
A2M
ALB
ALDOA
APP

CD36
CD9
CFD
CLU

EGF
F13A1
F5
F8

FGA
FGB
FGG
FN1

GP1BA
GP1BB
GP5
GP9

HGF
HRG
IGF1
ITGA2B

ITGB3
KNG1
MMRN1
PECAM1

PF4
PLG
PPBP
PRG1

PROS1
SELP
SERPINA1
SERPINE1

SERPINF2
SERPING1
SPARC
SRGN

TIMP1
TMSB4X
VWF
43
KEGG Pathway :
  sa03010
Ribosome 260.00
N/A
N/A
RPL26 < FN1 < ANGPTL4
RPL21 < FN1 < ANGPTL4
RPS3 < FN1 < ANGPTL4

RPLP0 < FN1 < ANGPTL4
RPS3A < FN1 < ANGPTL4
RPL17 < FN1 < ANGPTL4

RPL7A < FN1 < ANGPTL4
RPL7 < FN1 < ANGPTL4
RPS9 < FN1 < ANGPTL4

RPL6 < FN1 < ANGPTL4
RPS18 < TNF < ANGPTL4
RPL10A < FN1 < ANGPTL4

RPL4 < FN1 < ANGPTL4
13
RPL35
RPL10L
RPL22L1
FAU

RPL13A
RPL36
RSL24D1P11
MRPL13

RPSA
RPL10A
RPS27L
RPL26L1

RSL24D1
RPL3
RPL3L
RPL4

RPL5
RPL6
RPL7
RPL7A

RPL8
RPL9
RPL10
RPL11

RPL12
RPL13
RPL15
RPL17

RPL18
RPL18A
RPL19
RPL21

RPL22
RPL23A
RPL24
RPL26

RPL27
RPL30
RPL27A
RPL28

RPL29
RPL31
RPL32
RPL34

RPL35A
RPL36AL
RPL37
RPL37A

RPL38
RPL39
RPL41
RPL36A

RPLP0
RPLP1
RPLP2
RPS2

RPS3
RPS3A
RPS4X
RPS4Y1

RPS5
RPS6
RPS7
RPS8

RPS9
RPS10
RPS11
RPS12

RPS13
RPS15
RPS15A
RPS16

RPS17
RPS18
RPS19
RPS20

RPS21
RPS23
RPS24
RPS25

RPS26
RPS27
RPS27A
RPS28

RPS29
UBA52
RPL14
RPL23
88
Biocarta id :
  mad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling 250.00
N/A
FOXO1 < ANGPTL4
ITGB5 < VTN < ANGPTL4
SERPINE1 < VTN < ANGPTL4
NCOR1 < PPARA < ANGPTL4

AR < FOXO1 < ANGPTL4
COL1A2 < FN1 < ANGPTL4
SMAD4 < FOXO1 < ANGPTL4

SMAD4 < FN1 < ANGPTL4
CDKN1A < FOXO1 < ANGPTL4
CREBBP < FOXO1 < ANGPTL4

CREBBP < PPARA < ANGPTL4
EP300 < PPARA < ANGPTL4
12
CDK2
CDK4
CDKN1A
SAP18

CDKN2B
PIAS3
NCOA2
CEBPB

COL1A2
CREB1
ATF2
CREBBP

GSC
NKX2-5
CTBP1
DLX1

E2F4
E2F5
EP300
AKT1

ESR1
FOXG1
FOXO1
FOXO3

SIN3B
FOS
SIN3A
GATA3

KAT2A
NR3C1
HDAC1
HDAC2

HNF4A
HSPA8
IFNB1
IL5

IL10
IRF7
AR
ITGB5

JUN
LAMC1
SMAD2
SMAD3

SMAD4
SMAD7
MAX
MEF2C

FOXO4
CITED1
MYC
MYOD1

ATF3
SERPINE1
MED15
PIAS4

DCP1A
RBBP4
RBBP7
RBL1

TGIF2
SKI
SKIL
SP1

SP3
TCF3
TFDP1
TFE3

TGIF1
VDR
ZBTB17
SNIP1

RUNX2
RUNX1
RUNX3
NCOA1

CBFB
SAP30
KAT2B
FOXH1

NCOR1
81
KEGG Pathway :
  sa03320
PPAR signaling pathway 225.08
ANGPTL4
PPARA < ANGPTL4
LPL < ANGPTL4
FABP1 < PPARA < ANGPTL4
APOA1 < FN1 < ANGPTL4
NR1H3 < Ppara < Angptl4

NR1H3 < PPARA < ANGPTL4
CD36 < FN1 < ANGPTL4
RXRG < PPARA < ANGPTL4
9
NR1H3
SORBS1
SLC27A5
SLC27A4

SLC27A2
APOA5
CPT1C
CPT1A

CPT1B
CPT2
CYP4A11
CYP7A1

CYP8B1
CYP27A1
DBI
EHHADH

FABP4
FABP1
FABP2
FABP3

FABP5
FABP6
FABP7
ACSL1

ACSL3
ACSL4
ACSL6
GK

GK2
CYP4A22
SLC27A6
ACAA1

HMGCS2
ACADL
APOA1
APOA2

ACADM
APOC3
ILK
AQP7

SLC27A1
LPL
ME1
MMP1

OLR1
ACOX1
PCK1
PCK2

ANGPTL4
PDPK1
ACSL5
PLIN1

PLTP
PPARA
PPARD
PPARG

RXRA
RXRB
RXRG
SCD

SCP2
UBC
UCP1
SCD5

ACOX2
ACOX3
ADIPOQ
FADS2

CD36
69
Biocarta id :
  ivnefpathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha 130.00
N/A
TNF < ANGPTL4
nef < FN1 < ANGPTL4
nef < TNF < ANGPTL4
TNFRSF1A < TNF < ANGPTL4

FASLG < FN1 < ANGPTL4
RELA < PPARA < ANGPTL4
6
CHUK
nef
DAXX
DFFA

DFFB
APAF1
BIRC3
FAS

FASLG
MAP3K5
NFKB1
NFKBIA

CYCS
MAPK8
MAP2K7
BCL2

RELA
BID
TNF
TNFRSF1A

TRAF1
TRAF2
CASP2
CASP3

CASP6
CASP7
CASP8
CASP9

TRADD
RIPK1
CRADD
FADD

CFLAR
MAP3K14
CD247
BAG4
36
Biocarta id :
  ectin_pathway
Nectin adhesion pathway 120.00
N/A
N/A
PVR < VTN < ANGPTL4
ITGAV < FN1 < ANGPTL4
ITGAV < VTN < ANGPTL4

ITGB3 < VTN < ANGPTL4
SRC < FOXO1 < ANGPTL4
RAC1 < TNF < ANGPTL4
6
CRK
CTNNA1
CTNNB1
PIP5K1C

PVRL3
RAPGEF1
ITGAV
ITGB3

F11R
PDGFRB
PIK3CA
PIK3R1

PTK2
PTPRM
PVR
PVRL1

PVRL2
RAC1
RAP1A
RAP1B

SRC
TLN1
VAV2
IQGAP1

CLDN1
FARP2
CDC42
CDH1
28
Biocarta id :
  53hypoxiapathway
hypoxia and p53 in the cardiovascular system 115.08
N/A
N/A
IGFBP3 < FN1 < ANGPTL4
FHL2 < FOXO1 < ANGPTL4
GADD45A < Ppara < Angptl4

CDKN1A < FOXO1 < ANGPTL4
HSP90AA1 < PPARA < ANGPTL4
EP300 < PPARA < ANGPTL4
6
CDKN1A
GADD45A
DNAJB1P1
EP300

AKT1
FHL2
HIC1
HIF1A

HSPA1A
HSP90AA1
IGFBP3
MDM2

ATM
NFKBIB
ABCB1
MAPK8

BAX
RPA1
TAF1
TP53

UBE2A
21
PA164728217 BMP receptor signaling - (Pathway Interaction Database
NCI-Nature Curated)
100.00
N/A
N/A
SMAD9 < FN1 < ANGPTL4
SMAD4 < FOXO1 < ANGPTL4
SMAD4 < FN1 < ANGPTL4

GSK3B < FOXO1 < ANGPTL4
MAPK1 < PPARA < ANGPTL4
5
AHSG
BAMBI
BMP4
BMP6

BMP7
BMPR1A
BMPR1B
BMPR2

CER1
CHRD
CHRDL1
CTDSP2

FST
GREM1
GSK3B
MAP3K7

MAPK1
NOG
NUP214
PPM1A

PPP1CA
PPP1R15A
RGMA
SKI

SMAD1
SMAD4
SMAD5
SMAD7

SMAD9
SMURF1
SMURF2
SOSTDC1

XIAP
ZFYVE16
34
Biocarta id :
  pp1pathway
regulators of bone mineralization 100.00
N/A
N/A
SPP1 < FN1 < ANGPTL4
COL4A1 < FN1 < ANGPTL4
COL4A2 < FN1 < ANGPTL4

COL4A6 < FN1 < ANGPTL4
COL4A5 < FN1 < ANGPTL4
5
COL4A1
COL4A2
COL4A3
COL4A4

COL4A5
COL4A6
ALPL
IBSP

ENPP1
ANKH
SPP1
11
Biocarta id :
  nfr2pathway
tnfr2 signaling pathway 60.00
N/A
N/A
LTA < TNF < ANGPTL4
TNFRSF1B < TNF < ANGPTL4
RELA < PPARA < ANGPTL4
3
TANK
LTA
MAP3K1
NFKBIA

RELA
TNFAIP3
TNFRSF1B
TRAF1

TRAF2
TRAF3
RIPK1
MAP3K14
12
KEGG Pathway :
  tr03320
PPAR signaling pathway 49.67
ANGPTL4
N/A
N/A
1
APOA2
SORBS1
SCD
ACSL5

FADS2
CPT1A
MMP1
APOC3

APOA1
PCK2
SLC27A2
ACOX1

SLC27A1
SLC27A5
FABP3
LOC456835

SCP2
RXRG
PLTP
PCK1

PPARA
DBI
ACADL
LOC459951

ACSL3
PPARG
ACAA1
ACOX2

EHHADH
ACOX3
SCD5
UCP1

ACSL1
SLC27A6
FABP6
RXRB

PPARD
CD36
LPL
CYP7A1

FABP4
RXRA
LOC465043
NR1H3

UBC
PLIN1
ACADM
LOC470130

CPT1B
ADIPOQ
GK2
FABP7

LOC472619
OLR1
FABP1
LOC736962

CPT2
GK
LOC739864
FABP2

LOC740526
SLC27A4
ANGPTL4
LOC743807

FABP5
ILK
66
Reactome id :
  52
Generic Transcription Pathway - (Reactome via Pathway
Interaction Database)
40.00
N/A
N/A
MED1 < PPARA < ANGPTL4
MED24 < PPARA < ANGPTL4
2
CCNC
CDK8
MED1
MED12

MED13
MED14
MED15
MED16

MED17
MED20
MED24
MED26

MED27
MED30
MED31
MED4

MED6
MED7
MED8
MED8

MED8
MED8
22
Reactome id :
  93
Apoptotic cleavage of cellular proteins - (Reactome
via Pathway Interaction Database)
40.00
N/A
N/A
PRKCD < PPARA < ANGPTL4
BIRC2 < TNF < ANGPTL4
2
ACIN1
BCAP31
BIRC2
BMX

CASP3
CASP7
CASP8
CLSPN

FNTA
PRKCD
PRKCQ
PTK2

ROCK1
STK24
14
Biocarta id :
  edgehog_2pathway
Signaling events mediated by the Hedgehog family 40.00
N/A
N/A
LRP2 < LPL < ANGPTL4
TGFB2 < VTN < ANGPTL4
2
ADRBK1
AKT1
GAS1
GLI2

IHH
LRP2
LRPAP1
ARRB2

DHH
CDON
PIK3CA
PIK3R1

HHAT
PTCH1
PTHLH
HHIP

SHH
STIL
SMO
TGFB2

PTCH2
BOC
22
Reactome id :
  07
Negative regulation of the PI3K/AKT network - (Reactome
via Pathway Interaction Database)
20.00
N/A
N/A
TRIB3 < FN1 < ANGPTL4
1
AKT1
PTEN
THEM4
TRIB3
4
Reactome id :
  368
Chemokine receptors bind chemokines - (Reactome via
Pathway Interaction Database)
20.00
N/A
N/A
CXCL12 < FN1 < ANGPTL4
1
CCL16
CCL20
CCL25
CCL5

CCR10
CCR6
CCR7
CX3CL1

CXCL12
CXCL16
CXCR6
CXCR6

CXCR6
XCR1
14
PA164856985 Tachykinin receptors bind tachykinins - (Reactome via
Pathway Interaction Database)
20.00
N/A
N/A
TAC1 < FN1 < ANGPTL4
1
TAC1
TAC3
TACR1
TACR2

TACR3
5
Biocarta id :
  hcpathway
antigen processing and presentation 20.00
N/A
N/A
KLK3 < FN1 < ANGPTL4
1
HLA-A
HLA-DRA
HLA-DRB1
KLK3

B2M
PSMB5
PSMB6
PSMB8

PSMB9
TAP1
TAP2
CD74
12
*Total number of Query Gene in Pathway     **Total number of Genes in Pathway