Gene-Map Pathway-Top10 Query Gene ID: vat    Query Name : Gid    Query Size(No. of Amino Acid) :
Pathway ID▼
Pathway
name
Score
Relaxed Genes
in Pathway
1st interacting Gene
in Pathway
2nd interacting Gene
in Pathway
*N1
All Genes
in Pathway
**N2
Reactome id :
  5428
Regulation of Insulin-like Growth Factor (IGF) Activity
by Insulin-like Growth Factor Binding Proteins (IGFBPs)
2179.97
MMP2
MMP2

MMP2
Mmp2

MMP2
MMP2

mmp2
mmp2

MMP2
MMP2

mmp2
Mmp2

MMP2
MMP2

mmp2
MMP2

MMP2
MMP2

mmp2
PLG < MMP9
igfbp3 < mmp2

IGFBP3 < MMP2
IGFBP3 < MMP2

Igfbp3 < Mmp2
Igfbp3 < Mmp2

IGFBP3 < MMP2
Igf1 < Mmp2

Igf1 < Mmp2
Igf1 < Mmp2

Igf1 < Mmp2
Igf1 < Mmp2

Igf1 < Mmp2
Igf1 < Mmp2

Igf1 < Mmp2
Igf1 < Mmp2

Igf1 < Mmp2
Igf1 < Mmp2

Igf1 < Mmp2
IGF1 < MMP2

IGF1 < MMP2
IGF1 < MMP2

IGF1 < MMP2
IGF1 < MMP2

IGF1 < MMP2
IGF1 < MMP2

IGF1 < MMP2
IGF1 < MMP2

IGF1 < MMP2
IGF1 < MMP2

IGF1 < MMP2
MMP1 < MMP2

IGFBP3 < MMP2
IGFBP3 < MMP2
PAPPA2 < IGFBP3 < MMP2
CTSG < IGFBP3 < MMP2
KLK3 < A2M < MMP2

KLK3 < IGFBP3 < MMP2
IGFALS < IGFBP3 < MMP2
IGFBP5 < FN1 < MMP2

IGFBP5 < THBS1 < MMP2
IGFBP4 < tat < MMP2
IGF1 < tat < MMP2

IGF1 < env < MMP2
IGF1 < IGFBP3 < MMP2
IGF1 < FN1 < MMP2

PLG < IGFBP3 < MMP2
PLG < MMP3 < MMP2
PLG < MMP7 < MMP2

PLG < PCOLCE < MMP2
F2 < env < MMP2
F2 < IGFBP3 < MMP2

F2 < PLAU < MMP2
F2 < THBS1 < MMP2
73
CTSG
CTSG
CTSG
Ctsg

ctsG
ctsG
ctsg
ctsX

ctsG
CTSG
CTSG
Ctsg

CTSG
ctsG
CTSG
IQCF2

Ptgfrn
TRXF2
LOC100231982
ATP5J2

F2
LOC682013
PTGFRN
F2

f2
AFUA_4G09580
PTGFRN
atp5j2

AFLA_081910
Fam71f2
f2
Lmb1

SpyM50110
SLC35F2
F2
foxf2

Foxf2
F2
LOC100480103
FII

pepF2
atp5j2
Lmb4
endoS

LOC100077478
ccmF2
Atp5j2
F2

SLC35F2
SSO2154
LOC100224846
IQCF2

LOC100301612
NFIA_106430
FOXF2
SpyM3_0104

Iqcf2
f2
PTGFRN
endoS

f2
LOC100083623
SLC35F2
PAAG_07824

vpmaF2
Slc35f2
Ef-1a-f2
ACLA_048860

LOC100493252
PTGFRN
PTGFRN
SLC35F2

ATP5J2
IQCF2
PTGFRN
ATP5J2

f2
F2
PsVF_s2gp1
Ta0301

Fam71f2
gstf2
FOXF2
SLC35F2

PTGFRN
f2
ccmF2
SLC35F2

SLGD_01820
xopF2
ccmF2
slc35f2

PTGFRN
LOC100356337
Lmb2
BT_3753

f2
endoS
F2
ATP5J2P6

ATP5J2P3
SLC35F2
PTGFRN
SLGD_00719

foxf2
pepF2
pepF2
Atp5j2

f2
LOC100228202
Atp5j2
endOF2

endoS
MSV161
endoS
SPANXF2

SPSINT_0749
SLC35F2
F2
PTGFRN

endoS
ptgfrn
LOC364707
SLC35F2

SLC35F2
ATP5J2
Acav_4368
ATP5J2P5

slc35f2
LOC100540363
FAM71F2
l(2)F2

ATP5J2
ATP5J2P2
LOC100619486
Atp5j2

ccmF
F2
Aave_4472
F2

PTO0862
ATP5J2
Slc35f2
F2

ATP5J2P4
Iqcf2
FAM71F2
PRA7

EF1a-F2
IQCF2
PTGFRN
Ptgfrn

slc35f2
M6_Spy1530
PTGFRN
SPSINT_1974

IGF1
Igf1
IGF1
IGF1

igf1
IGF1
Igf1
IGF1

IGF1
igf1
Igf1
IGF1

IGF1
IGF1
IGF1
IGF1

IGF1
AaeL_AAEL006876
Igf2
igf2

CpipJ_CPIJ016544
IGF2
IGF2
igf2

igf2
IGF2
IGF2
CpipJ_CPIJ004648

CpipJ_CPIJ007610
LOC100114171
Igf2
IGF2

Igf2
Minute
LOC100304637
IGF2

LOC662768
IGF2
igf2
IGF2

IGF2
IGF2
CpipJ_CPIJ011349
IGF2

Igfals
IGFALS
LOC591034
IGFALS

IGFALS
IGFALS
Igfals
IGFALS

IGFALS
igfals
IGFALS
IGFBP1

Igfbp1
IGFBP1
IGFBP1
IGFBP1

IGFBP1
igfbp1
IGFBP1
Igfbp1

igfbp1
IGFBP1
IGFBP1
IGFBP1

Igfbp2
IGFBP2
IGFBP2
igfbp2

igfbp2
igfbp2
IGFBP2
IGFBP2

IGFBP2
IGFBP2
IGFBP2
IGFBP2

IGFBP2
igfbp2
IGFBP2
Igfbp2

igfbp3
Igfbp3
IGFBP3
IGFBP3

IGFBP3
IGFBP3
igfbp3
Igfbp3

IGFBP3
IGFBP3
IGFBP3
IGFBP3

IGFBP3
IGFBP4
IGFBP4
Igfbp4

IGFBP4
IGFBP4
IGFBP4
igfbp4

IGFBP4
Igfbp4
IGFBP4
IGFBP4

Igfbp5
IGFBP5
igfbp5
Igfbp5

IGFBP5
IGFBP5
IGFBP5
IGFBP5

IGFBP5
IGFBP5
igfbp5
igfbp5

IGFBP6
IGFBP6
IGFBP6
IGFBP6

Igfbp6
IGFBP6
Igfbp6
igfbp6

IGFBP6
igfbp6
KLK3
MmP1_gp34

MmP1_gp02
MmP1_gp45
NEWENTRY
MMP1

MmP1_gp38
MmP1_gp44
MMP1
MmP1_gp42

MmP1_gp46
MMP1
MmP1_gp20
MMP1

Mmp1
MMP1
MMP1
MMP1

mmp1
Mmp1
Mmp1
MmP1_gp07

MMP1
MmP1_gp08
MMP1
mmp1

MMP1
MMP1
MMP1
MmP1_gp15

MmP1_gp28
MmP1_gp33
MmP1_gp47
MmP1_gp12

MmP1_gp06
MmP1_gp39
MmP1_gp24
MmP1_gp23

MmP1_gp27
MmP1_gp49
MmP1_gp14
MMP1

MmP1_gp19
MmP1_gp13
MmP1_gp43
MmP1_gp10

MmP1_gp40
MmP1_gp11
MmP1_gp31
MmP1_gp41

MMP1
MmP1_gp09
MmP1_gp03
MmP1_gp18

MmP1_gp22
MmP1_gp17
MmP1_gp37
MmP1_gp35

MmP1_gp29
Mmp1
MmP1_gp30
MmP1_gp01

MmP1_gp48
mmp1
MmP1_gp36
MmP1_gp21

MmP1_gp32
MMP1
MmP1_gp25
MMP1

MmP1_gp16
MmP1_gp04
MmP1_gp26
MmP1_gp05

mmp2
MMP2
MMP2
MMP2

MMP2
MMP2
MMP2
mmp2

MMP2
MMP2
mmp2
Mmp2

MMP2
mmp2
Mmp2
MMP2

Mmp2
MMP2
MMP2
MMP2

MMP2
mmp2
MMP2
PAPPA

LOC100004323
Pappa
PAPPA
PAPPA

PAPPA
PAPPA
PAPPA
PAPPA

pappa
LOC567184
PAPPA
PAPPA-AS1

Pappa
PAPPA2
Pappa2
pappa2

pappa2
pappa2
PAPPA2
PAPPA2

PAPPA2
PAPPA2
PAPPA2
Pappa2

PAPPA2
PAPPA2
PAPPA2
PAPPA2

PAPPA2
PAPPA2
PLG
plg

plg
PLG
LOC100228354
PLG

PLG
PLG
Ot03g00230
Plg

PLG
Plg
PLG
plg

PLG
PLG
430
PA164714014 Integrin cell surface interactions - (Reactome via
Pathway Interaction Database)
1800.00
N/A
LAMA2 < MMP2
LAMB1 < MMP2

THBS1 < MMP2
THBS1 < MMP2

THBS1 < MMP2
ITGAV < MMP2

ITGAV < MMP2
ITGAV < MMP2

COL1A1 < MMP2
COL1A1 < MMP2

FN1 < MMP2
COL1A2 < MMP2
FBN1 < VCAN < MMP2
ITGA8 < FN1 < MMP2
LAMC3 < tat < MMP2

LAMC3 < LAMA2 < MMP2
LAMC3 < LAMB1 < MMP2
COL2A1 < MMP13 < MMP2

COL2A1 < PCOLCE < MMP2
COL2A1 < TGFB1 < MMP2
COL2A1 < THBS1 < MMP2

ITGB8 < ITGAV < MMP2
ITGB8 < TGFB1 < MMP2
ITGB8 < MMP14 < MMP2

ITGB6 < FN1 < MMP2
ITGB6 < ITGAV < MMP2
ITGB6 < TGFB1 < MMP2

ITGAX < env < MMP2
LAMC1 < tat < MMP2
LAMC1 < LAMA2 < MMP2

LAMC1 < LAMB1 < MMP2
ITGA6 < LAMB1 < MMP2
TNC < FN1 < MMP2

ITGAL < env < MMP2
ITGAM < env < MMP2
ITGA3 < env < MMP2

ITGA3 < TIMP2 < MMP2
ITGA3 < THBS1 < MMP2
ITGB5 < tat < MMP2

ITGB5 < ITGAV < MMP2
LAMA5 < COL7A1 < MMP2
LAMA5 < env < MMP2

BSG < env < MMP2
F11R < ITGAV < MMP2
VTN < FN1 < MMP2

VTN < ITGAV < MMP2
VTN < THBS1 < MMP2
LAMB2 < tat < MMP2

LAMA1 < COL7A1 < MMP2
LAMA1 < tat < MMP2
LAMA1 < LAMB1 < MMP2

SPP1 < ITGAV < MMP2
SPP1 < MMP3 < MMP2
SPP1 < FN1 < MMP2

SPP1 < THBS1 < MMP2
ITGA2 < COL1A1 < MMP2
ITGA2 < COL1A2 < MMP2

ITGA2 < MMP1 < MMP2
ITGA5 < COL6A3 < MMP2
ITGA5 < FN1 < MMP2

PECAM1 < FN1 < MMP2
ITGB7 < FN1 < MMP2
ITGB2 < tat < MMP2

ITGB2 < env < MMP2
ITGA4 < VCAN < MMP2
ITGA4 < env < MMP2

ITGA4 < THBS1 < MMP2
ITGA1 < COL6A3 < MMP2
CDH1 < HSP90AA1 < MMP2

ITGB3 < COL1A2 < MMP2
ITGB3 < tat < MMP2
ITGB3 < FN1 < MMP2

ITGB3 < ITGAV < MMP2
ITGB3 < COL6A3 < MMP2
ITGB3 < THBS1 < MMP2

ITGB1 < COL1A1 < MMP2
ITGB1 < tat < MMP2
ITGB1 < FN1 < MMP2

ITGB1 < MMP9 < MMP2
ITGB1 < TIMP2 < MMP2
ITGB1 < COL6A3 < MMP2

ITGB1 < ITGAV < MMP2
ITGB1 < THBS1 < MMP2
ITGB1 < THBS2 < MMP2
84
AMICA1
BSG
CDH1
COL1A1

COL1A2
COL2A1
F11R
FBN1

FGA
FGB
FGG
FN1

IBSP
ITGA1
ITGA10
ITGA11

ITGA2
ITGA2B
ITGA3
ITGA4

ITGA5
ITGA6
ITGA7
ITGA8

ITGA9
ITGAD
ITGAE
ITGAL

ITGAM
ITGAV
ITGAX
ITGB1

ITGB2
ITGB3
ITGB4
ITGB5

ITGB6
ITGB7
ITGB8
JAM2

JAM3
LAMA1
LAMA2
LAMA5

LAMB1
LAMB2
LAMC1
LAMC3

MADCAM1
PECAM1
SPP1
THBS1

TNC
VCAM1
VTN
55
KEGG Pathway :
  sa04310
Wnt signaling pathway 1641.38
N/A
SFRP2 < MMP2
SFRP4 < MMP2

MMP7 < MMP2
LRP5 < THBS1 < MMP2
PPP2R5B < tat < MMP2
PPP2R5B < env < MMP2

PPP2R5A < tat < MMP2
PPP2R5C < tat < MMP2
PPP2R5E < tat < MMP2

CSNK1A1 < LGALS3 < MMP2
CSNK2A1 < IGFBP3 < MMP2
CSNK2A2 < LGALS3 < MMP2

PSEN1 < BACE1 < MMP2
WNT1 < SFRP2 < MMP2
PPP2R1A < tat < MMP2

PPP2R1B < tat < MMP2
CCND3 < tat < MMP2
PPP2CB < tat < MMP2

PPP2CA < tat < MMP2
AXIN1 < Smad3 < Mmp2
NFATC3 < tat < MMP2

NFATC3 < env < MMP2
NFATC1 < tat < MMP2
NFATC1 < env < MMP2

CUL1 < OSBPL10 < MMP2
NFATC2 < tat < MMP2
NFATC2 < env < MMP2

MAP3K7 < HSP90AA1 < MMP2
NFATC4 < tat < MMP2
NFATC4 < env < MMP2

SMAD4 < AR < MMP9
SMAD4 < FOSB < MMP2
SMAD3 < tat < MMP2

SMAD3 < Smad3 < Mmp2
SMAD3 < FOSB < MMP2
SMAD3 < TGFB1 < MMP2

CAMK2B < tat < MMP2
CAMK2A < tat < MMP2
TCF7L2 < tat < MMP2

EP300 < tat < MMP2
EP300 < env < MMP2
EP300 < Stat3 < Mmp2

CREBBP < tat < MMP2
CREBBP < FGFR1 < MMP2
CREBBP < AR < MMP9

PPP3CB < tat < MMP2
PPP3CC < tat < MMP2
PPP3R2 < tat < MMP2

JUN < tat < MMP2
JUN < env < MMP2
MYC < HSP90AA1 < MMP2

PLCB3 < tat < MMP2
PLCB3 < env < MMP2
PLCB4 < env < MMP2

RAC3 < AR < MMP9
CTNNB1 < AR < MMP9
CTNNB1 < HSP90AA1 < MMP2

PLCB2 < tat < MMP2
RAC2 < tat < MMP2
GSK3B < tat < MMP2

GSK3B < AR < MMP9
MAPK8 < tat < MMP2
MAPK8 < env < MMP2

MAPK10 < env < MMP2
MAPK9 < env < MMP2
MAPK9 < Stat3 < Mmp2

CCND1 < tat < MMP2
CCND1 < AR < MMP9
PRKACB < env < MMP2

PRKACA < env < MMP2
PRKACA < CIITA < MMP9
PRKACG < env < MMP2

PRKCG < tat < MMP2
PRKCG < env < MMP2
TP53 < tat < MMP2

TP53 < env < MMP2
TP53 < Smad3 < Mmp2
TP53 < HSP90AA1 < MMP2

TP53 < AR < MMP9
RAC1 < tat < MMP2
PRKCA < tat < MMP2

PRKCA < env < MMP2
PRKCA < HSP90AA1 < MMP2
PRKCB < tat < MMP2

PRKCB < env < MMP2
85
FRAT1
APC2
NFAT5
WIF1

FZD10
CHP
CSNK1A1L
CREBBP

PRICKLE1
CSNK1A1
CSNK1E
CSNK2A1

CSNK2A2
CSNK2B
CTBP1
CTBP2

CTNNB1
PRICKLE2
DVL1
DVL2

DVL3
EP300
DKK1
DAAM1

PLCB1
FBXW11
FRAT2
DAAM2

FZD2
CACYBP
DKK4
DKK2

GSK3B
APC
JUN
RHOA

LRP6
LRP5
SMAD2
SMAD3

SMAD4
MMP7
MYC
NFATC1

NFATC2
NFATC3
NFATC4
LEF1

WNT16
NLK
PLCB2
PLCB3

PLCB4
WNT4
PPARD
PPP2CA

PPP2CB
PPP2R1A
PPP2R1B
PPP2R5A

PPP2R5B
PPP2R5C
PPP2R5D
PPP2R5E

PPP3CA
PPP3CB
PPP3CC
PPP3R1

PPP3R2
PRKACA
PRKACB
PRKACG

PRKCA
PRKCB
PRKCG
MAPK8

MAPK9
MAPK10
PRKX
PSEN1

CTNNBIP1
VANGL2
CHD8
RAC1

RAC2
RAC3
SENP2
CCND1

ROCK1
CHP2
SFRP1
SFRP2

SFRP4
SFRP5
SOX17
SIAH1

PORCN
SKP1
MAP3K7
TBL1X

TCF7
TCF7L2
TP53
LOC728622

WNT1
WNT2
WNT3
WNT5A

WNT6
WNT7A
WNT7B
WNT8A

WNT8B
WNT10B
WNT11
WNT2B

WNT9A
WNT9B
FZD5
TBL1XR1

FZD3
CXXC4
WNT10A
FOSL1

WNT5B
CAMK2A
CAMK2B
CAMK2D

CAMK2G
VANGL1
AXIN1
AXIN2

FZD1
FZD4
FZD6
FZD7

FZD8
FZD9
TCF7L1
CUL1

NKD1
NKD2
RUVBL1
CCND2

BTRC
CCND3
WNT3A
TBL1Y

CER1
ROCK2
RBX1
151
Biocarta id :
  mad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling 1526.23
N/A
COL1A2 < MMP2
AR < MMP9

AR < MMP9
AR < MMP9

AR < MMP9
AR < MMP9

AR < MMP9
AR < MMP9

AR < MMP9
AR < MMP9

AR < MMP9
AR < MMP9

AR < MMP9
AR < MMP9
IFNB1 < tat < MMP2
IFNB1 < env < MMP2
LAMC1 < tat < MMP2

LAMC1 < LAMA2 < MMP2
LAMC1 < LAMB1 < MMP2
RUNX1 < AR < MMP9

SP3 < tat < MMP2
SKIL < FN1 < MMP2
CBFB < COL7A1 < MMP2

ITGB5 < tat < MMP2
ITGB5 < ITGAV < MMP2
TGIF1 < AR < MMP9

HSPA8 < env < MMP2
HSPA8 < HSP90AA1 < MMP2
IL10 < tat < MMP2

IL10 < env < MMP2
IL10 < A2M < MMP2
E2F4 < tat < MMP2

TCF3 < tat < MMP2
RUNX2 < AR < MMP9
PIAS3 < AR < MMP9

VDR < env < MMP2
RBBP7 < HSP90AA1 < MMP2
PIAS4 < AR < MMP9

SIN3B < HSP90AA1 < MMP2
NR3C1 < HSP90AA1 < MMP2
NR3C1 < AR < MMP9

SIN3A < HSP90AA1 < MMP2
SIN3A < AR < MMP9
KAT2A < tat < MMP2

SERPINE1 < tat < MMP2
SERPINE1 < PLAU < MMP2
SMAD7 < env < MMP2

MAX < env < MMP2
CDK4 < tat < MMP2
CDK4 < HSP90AA1 < MMP2

NCOR1 < AR < MMP9
NCOA1 < tat < MMP2
NCOA1 < Nfkb1 < Mmp2

NCOA1 < AR < MMP9
NCOA1 < CIITA < MMP9
SMAD3 < tat < MMP2

SMAD3 < Smad3 < Mmp2
SMAD3 < FOSB < MMP2
SMAD3 < TGFB1 < MMP2

NCOA2 < AR < MMP9
KAT2B < tat < MMP2
FOXO1 < AR < MMP9

ESR1 < env < MMP2
ESR1 < AR < MMP9
CEBPB < tat < MMP2

CDK2 < tat < MMP2
SMAD4 < AR < MMP9
SMAD4 < FOSB < MMP2

CDKN1A < env < MMP2
SP1 < tat < MMP2
SP1 < AR < MMP9

HDAC1 < AR < MMP9
CREB1 < tat < MMP2
MYC < HSP90AA1 < MMP2

CREBBP < tat < MMP2
CREBBP < FGFR1 < MMP2
CREBBP < AR < MMP9

EP300 < tat < MMP2
EP300 < env < MMP2
EP300 < Stat3 < Mmp2

FOS < tat < MMP2
FOS < env < MMP2
FOS < EPHB2 < MMP2

JUN < tat < MMP2
JUN < env < MMP2
AKT1 < tat < MMP2

AKT1 < env < MMP2
AKT1 < HSP90AA1 < MMP2
AKT1 < AR < MMP9
89
CDK2
CDK4
CDKN1A
SAP18

CDKN2B
PIAS3
NCOA2
CEBPB

COL1A2
CREB1
ATF2
CREBBP

GSC
NKX2-5
CTBP1
DLX1

E2F4
E2F5
EP300
AKT1

ESR1
FOXG1
FOXO1
FOXO3

SIN3B
FOS
SIN3A
GATA3

KAT2A
NR3C1
HDAC1
HDAC2

HNF4A
HSPA8
IFNB1
IL5

IL10
IRF7
AR
ITGB5

JUN
LAMC1
SMAD2
SMAD3

SMAD4
SMAD7
MAX
MEF2C

FOXO4
CITED1
MYC
MYOD1

ATF3
SERPINE1
MED15
PIAS4

DCP1A
RBBP4
RBBP7
RBL1

TGIF2
SKI
SKIL
SP1

SP3
TCF3
TFDP1
TFE3

TGIF1
VDR
ZBTB17
SNIP1

RUNX2
RUNX1
RUNX3
NCOA1

CBFB
SAP30
KAT2B
FOXH1

NCOR1
81
Biocarta id :
  if1_tfpathway
HIF-1-alpha transcription factor network 1143.50
N/A
CXCL12 < MMP2
CXCL12 < MMP2

CXCL12 < MMP2
NT5E < FN1 < MMP2
ABCB1 < tat < MMP2
ALDOA < OSBPL10 < MMP2

ENG < TGFB1 < MMP2
LDHA < tat < MMP2
LDHA < env < MMP2

LEP < A2M < MMP2
TF < FN1 < MMP2
TF < IGFBP3 < MMP2

EDN1 < tat < MMP2
EDN1 < env < MMP2
NDRG1 < HSP90AA1 < MMP2

TFRC < env < MMP2
ITGB2 < tat < MMP2
ITGB2 < env < MMP2

NOS2 < tat < MMP2
NOS2 < env < MMP2
TERT < env < MMP2

TERT < HSP90AA1 < MMP2
ARNT < HSP90AA1 < MMP2
CXCR4 < tat < MMP2

CXCR4 < env < MMP2
CXCR4 < CXCL12 < MMP2
SERPINE1 < tat < MMP2

SERPINE1 < PLAU < MMP2
NCOA1 < tat < MMP2
NCOA1 < Nfkb1 < Mmp2

NCOA1 < AR < MMP9
NCOA1 < CIITA < MMP9
SMAD3 < tat < MMP2

SMAD3 < Smad3 < Mmp2
SMAD3 < FOSB < MMP2
SMAD3 < TGFB1 < MMP2

NCOA2 < AR < MMP9
ETS1 < AR < MMP9
VEGFA < tat < MMP2

VEGFA < env < MMP2
SMAD4 < AR < MMP9
SMAD4 < FOSB < MMP2

SP1 < tat < MMP2
SP1 < AR < MMP9
CREB1 < tat < MMP2

CREBBP < tat < MMP2
CREBBP < FGFR1 < MMP2
CREBBP < AR < MMP9

EP300 < tat < MMP2
EP300 < env < MMP2
EP300 < Stat3 < Mmp2

FOS < tat < MMP2
FOS < env < MMP2
FOS < EPHB2 < MMP2

JUN < tat < MMP2
JUN < env < MMP2
AKT1 < tat < MMP2

AKT1 < env < MMP2
AKT1 < HSP90AA1 < MMP2
AKT1 < AR < MMP9
60
CITED2
NDRG1
NCOA2
COPS5

EGLN3
PLIN2
ADM
CP

CREB1
CREBBP
EDN1
ENG

ENO1
EP300
EPO
AKT1

ETS1
FECH
ALDOA
FOS

GATA2
GCK
HIF1A
HK1

HK2
HMOX1
HNF4A
ID2

IGFBP1
ITGB2
JUN
LDHA

LEP
ARNT
SMAD3
SMAD4

MCL1
NOS2
NPM1
NT5E

FURIN
SERPINE1
HDAC7
PFKFB3

PFKL
PGK1
PGM1
ABCB1

PKM2
EGLN1
RORA
CXCL12

SLC2A1
BNIP3
SP1
TERT

TF
TFF3
TFRC
VEGFA

CA9
CXCR4
BHLHE41
BHLHE40

NCOA1
ABCG2
66
KEGG Pathway :
  sa04622
RIG-I-like receptor signaling pathway 1064.52
N/A
N/A
AZI2 < HSP90AA1 < MMP2
TBKBP1 < HSP90AA1 < MMP2
ISG15 < tat < MMP2

TANK < HSP90AA1 < MMP2
IKBKE < HSP90AA1 < MMP2
TRADD < HSP90AA1 < MMP2

TBK1 < HSP90AA1 < MMP2
IFNW1 < env < MMP2
RIPK1 < Nfkb1 < Mmp2

RIPK1 < HSP90AA1 < MMP2
CXCL10 < tat < MMP2
CXCL10 < env < MMP2

IFNB1 < tat < MMP2
IFNB1 < env < MMP2
IL12B < tat < MMP2

IL12B < env < MMP2
IL12A < tat < MMP2
IL12A < env < MMP2

TRAF2 < HSP90AA1 < MMP2
MAP3K7 < HSP90AA1 < MMP2
IL8 < tat < MMP2

IL8 < env < MMP2
IL8 < MMP9 < MMP2
NFKBIB < tat < MMP2

NFKBIB < env < MMP2
IFNA2 < env < MMP2
IFNA1 < tat < MMP2

IFNA1 < env < MMP2
IFNA7 < env < MMP2
IFNA16 < env < MMP2

CASP8 < AR < MMP9
MAPK14 < env < MMP2
NFKBIA < tat < MMP2

NFKBIA < env < MMP2
NFKBIA < Nfkb1 < Mmp2
CHUK < HSP90AA1 < MMP2

NFKB1 < tat < MMP2
NFKB1 < env < MMP2
NFKB1 < AR < MMP9

RELA < tat < MMP2
RELA < Nfkbia < Mmp2
RELA < AR < MMP9

MAPK8 < tat < MMP2
MAPK8 < env < MMP2
IKBKG < HSP90AA1 < MMP2

MAPK10 < env < MMP2
MAPK9 < env < MMP2
MAPK9 < Stat3 < Mmp2

IKBKB < env < MMP2
IKBKB < HSP90AA1 < MMP2
TNF < tat < MMP2

TNF < env < MMP2
TNF < DCN < MMP2
TNF < MMP17 < MMP2

TNF < SPOCK1 < MMP2
55
TANK
CHUK
MAPK14
CYLD

DDX3X
DDX58
DAK
TBK1

IFNE
TMEM173
IFNA1
IFNA2

IFNA4
IFNA5
IFNA6
IFNA7

IFNA8
IFNA10
IFNA13
IFNA14

IFNA16
IFNA17
IFNA21
IFNB1

IFNW1
IKBKB
IL8
IL12A

IL12B
CXCL10
IRF3
IRF7

MAP3K1
NFKB1
NFKBIA
NFKBIB

PIN1
RNF125
OTUD5
MAPK8

MAPK11
MAPK9
MAPK10
MAPK13

IFNK
MAVS
RELA
MAPK12

IFIH1
AZI2
MAP3K7
TNF

TRAF2
TRAF3
TRAF6
TRIM25

DHX58
NLRX1
SIKE1
CASP8

CASP10
IKBKG
DDX3Y
TRADD

RIPK1
FADD
ATG12
ATG5

ISG15
IKBKE
TBKBP1
71
Biocarta id :
  tp1bpathway
Signaling events mediated by PTP1B 819.17
N/A
N/A
NOX4 < env < MMP2
YBX1 < tat < MMP2
CAPN1 < COL3A1 < MMP2

FCGR2A < LGALS3 < MMP2
LEP < A2M < MMP2
TXN < env < MMP2

CAV1 < IGFBP3 < MMP2
ITGB3 < COL1A2 < MMP2
ITGB3 < tat < MMP2

ITGB3 < FN1 < MMP2
ITGB3 < ITGAV < MMP2
ITGB3 < COL6A3 < MMP2

ITGB3 < THBS1 < MMP2
YES1 < EPHB2 < MMP2
LYN < env < MMP2

EGFR < HBEGF < MMP2
EGFR < HSP90AA1 < MMP2
LCK < env < MMP2

LCK < HSP90AA1 < MMP2
STAT5A < env < MMP2
STAT3 < HSP90AA1 < MMP2

CRK < FGFR1 < MMP2
FYN < env < MMP2
FYN < HSP90AA1 < MMP2

FYN < FN1 < MMP2
FYN < ITGAV < MMP2
SHC1 < tat < MMP2

SHC1 < FGFR1 < MMP2
GRB2 < tat < MMP2
GRB2 < EPHB2 < MMP2

SRC < tat < MMP2
SRC < EPHB2 < MMP2
SRC < HSP90AA1 < MMP2

SRC < AR < MMP9
AKT1 < tat < MMP2
AKT1 < env < MMP2

AKT1 < HSP90AA1 < MMP2
AKT1 < AR < MMP9
PIK3CA < tat < MMP2

PIK3CA < env < MMP2
PIK3R1 < env < MMP2
PIK3R1 < FGFR1 < MMP2
42
CDH2
SPRY2
CRK
CSF1

CSF1R
CSK
CSN2
DOK1

EGF
EGFR
AKT1
FCGR2A

FER
FGR
FYN
LAT

GRB2
HCK
INS
INSR

IRS1
ITGA2B
ITGB3
JAK2

RHOA
LCK
LEP
LEPR

LYN
YBX1
NOX4
PDGFRB

PIK3CA
PIK3R1
TRPV6
PRL

PRLR
PTPN1
BLK
SHC1

SRC
STAT3
STAT5A
STAT5B

TXN
TYK2
YES1
CAPN1

CAV1
SOCS3
BCAR1
51
PA164713606 fc epsilon receptor i signaling in mast cells - (BioCarta
via Pathway Interaction Database)
759.17
N/A
N/A
MS4A2 < HSP90AA1 < MMP2
PRKCB < tat < MMP2
PRKCB < env < MMP2

PLA2G1B < env < MMP2
LYN < env < MMP2
MAP2K2 < tat < MMP2

MAP2K2 < HSP90AA1 < MMP2
FOS < tat < MMP2
FOS < env < MMP2

FOS < EPHB2 < MMP2
PLCG1 < env < MMP2
PLCG1 < EPHB2 < MMP2

PLCG1 < FGFR1 < MMP2
RAF1 < HSP90AA1 < MMP2
RAF1 < AR < MMP9

JUN < tat < MMP2
JUN < env < MMP2
MAP2K1 < tat < MMP2

MAP2K1 < env < MMP2
MAP2K1 < PLAU < MMP2
MAP2K1 < EPHB2 < MMP2

MAP2K1 < HSP90AA1 < MMP2
MAPK8 < tat < MMP2
MAPK8 < env < MMP2

MAPK3 < tat < MMP2
MAPK3 < env < MMP2
SOS1 < FGFR1 < MMP2

SHC1 < tat < MMP2
SHC1 < FGFR1 < MMP2
MAPK1 < tat < MMP2

MAPK1 < env < MMP2
MAPK1 < AR < MMP9
MAPK1 < ITGAV < MMP2

GRB2 < tat < MMP2
GRB2 < EPHB2 < MMP2
PIK3CA < tat < MMP2

PIK3CA < env < MMP2
PIK3R1 < env < MMP2
PIK3R1 < FGFR1 < MMP2
39
BTK
ELK1
FCER1A
FCER1G

FOS
GRB2
HRAS
JUN

LYN
MAP2K1
MAP2K2
MAP2K4

MAP2K7
MAP3K1
MAPK1
MAPK3

MAPK8
MS4A2
PAK2
PIK3CA

PIK3R1
PLA2G1B
PLCG1
PRKCB

RAF1
SHC1
SOS1
SYK

VAV1
29
Reactome id :
  2166
Binding of RNA by Insulin-like Growth Factor-2 mRNA
Binding Proteins (IGF2BPs/IMPs/VICKZs)
672.91
N/A
CD44 < MMP9
CD44 < MMP9

CD44 < MMP9
LOC100454957 < MMP9

LOC100454957 < MMP9
LOC100454957 < MMP9

LOC100454957 < MMP9
LOC100454957 < MMP9

LOC100454957 < MMP9
LOC100454957 < MMP9

LOC100454957 < MMP9
LOC100454957 < MMP9

LOC100454957 < MMP9
LOC100454957 < MMP9

LOC100454957 < MMP9
LOC100454957 < MMP9

LOC100454957 < MMP9
CD44 < MMP9

CD44 < MMP9
CD44 < MMP9

CD44 < MMP9
CD44 < MMP9

CD44 < MMP9
CD44 < MMP9

CD44 < MMP9
CD44 < MMP9

CD44 < MMP9
CD44 < MMP9

CD44 < MMP9
CD44 < MMP9

CD44 < MMP9
MYC < HSP90AA1 < MMP2
MAX < env < MMP2
CD44 < COL1A1 < MMP2

CD44 < HBEGF < MMP2
CD44 < MMP1 < MMP2
CD44 < MMP9 < MMP2

Myc < Bax < Mmp2
Myc < Cav1 < Mmp2
Myc < Thbs1 < Mmp2

ACTB < tat < MMP2
ACTB < AR < MMP9
ACTB < CIITA < MMP9

ACTB < HSP90AA1 < MMP2
44
Actb
actB
actB
actb

LILAB_23850
ACTB
ACTB
ACTB

ACTB
LOC100085078
Gm15725
ACTB

actb
ACTB
ACTB
actb

ACTB
actb
ACTB
Actb

ACTB
ACTB
actb
ACTB

ACTB
ACTB
Actb
ACTB

ACTB
CD44
LOC100475724
CD44

LOC100009826
CD44
LOC100627267
CD44

LOC100563382
LOC100544179
LOC100076581
CD44

cd44
CD44
CD44
cd44

CD44
LOC100525150
LOC100454957
Cd44

Cd44
CD44
LOC100219057
CD44

CD44
CD44
Huc2
H19

H19
Huc1
H19
H19

H19
V1rh19
H19
H19

H19
AaeL_AAEL006876
Igf2
igf2

CpipJ_CPIJ016544
IGF2
IGF2
igf2

igf2
IGF2
IGF2
CpipJ_CPIJ004648

CpipJ_CPIJ007610
LOC100114171
Igf2
IGF2

Igf2
Minute
LOC100304637
IGF2

LOC662768
IGF2
igf2
IGF2

IGF2
IGF2
CpipJ_CPIJ011349
IGF2

IGF2BP1
IGF2BP1
IGF2BP1
IGF2BP1

IGF2BP1
Igf2bp1
Igf2bp1
igf2bp1

IGF2BP1
IGF2BP1
IGF2BP1
IGF2BP1

IGF2BP1
IGF2BP1
IGF2BP2
IGF2BP2

IGF2BP2
Igf2bp2
IGF2BP2
IGF2BP2

LOC799856
IGF2BP2
IGF2BP2
IGF2BP2

IGF2BP2
IGF2BP2
igf2bp2
IGF2BP2

Igf2bp2
IGF2BP2
Igf2bp3
igf2bp3

IGF2BP3
IGF2BP3
IGF2BP3
IGF2BP3

IGF2BP3
IGF2BP3
IGF2BP3
IGF2BP3

IGF2BP3
IGF2BP3
igf2bp3
IGF2BP3

Igf2bp3
MYCBP2
LOC720503
mml-1

LOC683017
LOC685122
Mina
MAX

LOC100068097
Mina
LOC100341449
MINA

LOC782134
MYCT1
LOC364636
LOC100354656

Gm12047
LOC100464396
MINA
MYC

LOC100350249
MYCBP2
Mycbp2
LOC100392436

LOC100377027
LOC100483262
Gm18413
LOC100558533

MYCT1
max-a
LOC502653
LOC100563774

myc
LOC100543091
LOC100537522
LOC100250607

LOC100547931
Max
LOC100032344
LOC100219849

4930515G16Rik
LOC100060221
LOC100581647
LOC100619864

mina
MYCBP2
LOC100636430
MINA

LOC563561
MYC
mycbp2
LOC373385

LOC100589322
LOC100183875
mina
MINA

max
MAX
MYCBP2
myc7

LOC607260
MAX
MYCT1
Myc

myc1
MYC
Lmyc2
LOC100557585

LOC100081085
mycbp2
MYCBP2
LOC100410334

RCOM_0169210
myct1
max-b
MYC

LOC689439
MAX
myc2
LOC100515064

Mycbp2
MYCBP2
myc
Urml

Phum_PHUM566250
Myc
MYC
MYC

LOC100339083
MYC
MYCT1
MINA

LOC100180100
LOC607507
MINA
LOC726271

LOC100407797
myc
minal
myc

MYCBP2
MINA
MYCA1
MYCBP2

MINA
MYCBP2
LOC100348240
myc

LOC100224418
myct1
MYCBP2
MINA

LOC502078
LOC100179783
MYCBP2
Myct1

MINA
MINA
MINA
MYCT1

MAX
MINA
Myct1
max

LOC100386630
LOC100517734
LOC100225271
Tg.Myc

myc
mycbp2
myct1
LOC100456735

MYCT1
MYCBP2
MYC
MYC

MYC
LOC100407754
274
Biocarta id :
  53hypoxiapathway
hypoxia and p53 in the cardiovascular system 587.05
N/A
IGFBP3 < MMP2
IGFBP3 < MMP2

HSP90AA1 < MMP2
TAF1 < tat < MMP2
RPA1 < tat < MMP2
ABCB1 < tat < MMP2

NFKBIB < tat < MMP2
NFKBIB < env < MMP2
HSPA1A < tat < MMP2

HSPA1A < env < MMP2
HSPA1A < HSP90AA1 < MMP2
BAX < tat < MMP2

BAX < env < MMP2
MDM2 < tat < MMP2
CDKN1A < env < MMP2

TP53 < tat < MMP2
TP53 < env < MMP2
TP53 < Smad3 < Mmp2

TP53 < HSP90AA1 < MMP2
TP53 < AR < MMP9
EP300 < tat < MMP2

EP300 < env < MMP2
EP300 < Stat3 < Mmp2
MAPK8 < tat < MMP2

MAPK8 < env < MMP2
AKT1 < tat < MMP2
AKT1 < env < MMP2

AKT1 < HSP90AA1 < MMP2
AKT1 < AR < MMP9
29
CDKN1A
GADD45A
DNAJB1P1
EP300

AKT1
FHL2
HIC1
HIF1A

HSPA1A
HSP90AA1
IGFBP3
MDM2

ATM
NFKBIB
ABCB1
MAPK8

BAX
RPA1
TAF1
TP53

UBE2A
21
Biocarta id :
  rbb1_internalization_pathway
Internalization of ErbB1 499.17
N/A
N/A
VPS24 < env < MMP2
DNM1 < HSP90AA1 < MMP2
PIK3CB < tat < MMP2

PIK3CB < env < MMP2
EGFR < HBEGF < MMP2
EGFR < HSP90AA1 < MMP2

NRAS < env < MMP2
KRAS < env < MMP2
PTK2 < tat < MMP2

PTK2 < EPHB2 < MMP2
PTK2 < ITGAV < MMP2
RAF1 < HSP90AA1 < MMP2

RAF1 < AR < MMP9
SOS1 < FGFR1 < MMP2
SHC1 < tat < MMP2

SHC1 < FGFR1 < MMP2
GRB2 < tat < MMP2
GRB2 < EPHB2 < MMP2

SRC < tat < MMP2
SRC < EPHB2 < MMP2
SRC < HSP90AA1 < MMP2

SRC < AR < MMP9
PIK3CA < tat < MMP2
PIK3CA < env < MMP2

PIK3R1 < env < MMP2
PIK3R1 < FGFR1 < MMP2
26
SPRY2
STAMBP
DNM1
EGF

EGFR
EPS15
LRIG1
AMPH

GRB2
EPN1
SH3KBP1
HRAS

KRAS
NRAS
VPS24
PIK3CA

PIK3CB
PIK3R1
PTK2
ZFYVE28

RAB5A
RAF1
ITSN1
SH3GL2

SHC1
SOS1
SRC
TSG101

UBE2D1
UBE2D2
UBE2D3
CBL

CBLB
SYNJ1
ARHGEF7
USP8

HGS
CDC42
38
PA164713655 b cell survival pathway - (BioCarta via Pathway Interaction
Database)
458.11
N/A
N/A
ZBTB7A < tat < MMP2
ZBTB7A < Sp1 < Mmp2
BIRC5 < HSP90AA1 < MMP2

ITGA1 < COL6A3 < MMP2
ITGB1 < COL1A1 < MMP2
ITGB1 < tat < MMP2

ITGB1 < FN1 < MMP2
ITGB1 < MMP9 < MMP2
ITGB1 < TIMP2 < MMP2

ITGB1 < COL6A3 < MMP2
ITGB1 < ITGAV < MMP2
ITGB1 < THBS1 < MMP2

ITGB1 < THBS2 < MMP2
CASP3 < tat < MMP2
CASP3 < env < MMP2

CASP3 < AR < MMP9
AKT1 < tat < MMP2
AKT1 < env < MMP2

AKT1 < HSP90AA1 < MMP2
AKT1 < AR < MMP9
PIK3CA < tat < MMP2

PIK3CA < env < MMP2
PIK3R1 < env < MMP2
PIK3R1 < FGFR1 < MMP2
24
AKT1
BIRC5
CASP3
CASP7

CCT4
DPF2
ITGA1
ITGB1

PDPK1
PIK3CA
PIK3R1
ZBTB7A
12
KEGG Pathway :
  sa03040
Spliceosome 400.00
N/A
N/A
SFRS1 < tat < MMP2
SNRPD2 < tat < MMP2
RBMX < HSP90AA1 < MMP2

CRNKL1 < HSP90AA1 < MMP2
PRPF40A < MMP11 < MMP2
DDX5 < FN1 < MMP2

TCERG1 < tat < MMP2
USP39 < USP12 < MMP2
SNRPB < tat < MMP2

SNRPD1 < LGALS3 < MMP2
SNRPD3 < tat < MMP2
HSPA2 < tat < MMP2

HSPA2 < env < MMP2
HSPA1B < env < MMP2
HSPA6 < tat < MMP2

HSPA8 < env < MMP2
HSPA8 < HSP90AA1 < MMP2
HSPA1A < tat < MMP2

HSPA1A < env < MMP2
HSPA1A < HSP90AA1 < MMP2
20
PQBP1
THOC4
SF3B4
SMNDC1

BCAS2
SF3A1
PPIE
PPIH

CHERP
SLU7
PRPF8
USP39

SFRS13A
TXNL4A
TCERG1
SFRS2B

SF3A3
SF3B2
SNRNP27
LSM6

DDX42
U2AF2
LOC120364
HNRNPA1L2

CCDC12
ZMAT2
DDX5
DHX8

DHX15
HNRNPA3
PUF60
NCBP2

SNW1
ACIN1
SNRNP200
SR140

SF3B3
SF3B1
LSM5
PRPF6

PRPF40B
LSM4
SYF2
PRPF31

LSM3
RBMX
PRPF19
TRA2A

HNRNPA1
HNRNPC
HNRNPK
HNRNPU

HSPA1A
HSPA1B
HSPA1L
HSPA2

HSPA6
HSPA8
MAGOH
HNRNPM

NCBP1
NHP2L1
PCBP1
CRNKL1

CDC40
CWC15
SF3B14
PPIL1

LSM7
NAA38
WBP11
PLRG1

MAGOHB
PRPF38B
PRPF40A
RBM22

CTNNBL1
XAB2
THOC2
ISY1

LSM2
RBM25
SFRS1
SFRS2

SFRS3
SFRS4
SFRS5
SFRS6

SFRS7
TRA2B
LOC653884
SNRNP70

SNRPA
SNRPA1
SNRPB
SNRPB2

SNRPC
SNRPD1
SNRPD2
SNRPD3

SNRPE
SNRPF
SNRPG
U2AF1

BAT1
SF3A2
SF3B5
THOC3

DHX16
PHF5A
PRPF38A
RBM17

PRPF18
SFRS9
BUD31
SART1

PRPF4
PRPF3
EFTUD2
SNRNP40

DDX23
AQR
EIF4A3
DHX38

DDX46
CDC5L
RBM8A
THOC1
128
Biocarta id :
  roteasomepathway
proteasome complex 380.00
N/A
N/A
PSMD4 < tat < MMP2
PSMB7 < tat < MMP2
PSMD3 < tat < MMP2

PSMB4 < tat < MMP2
PSMA5 < tat < MMP2
PSMB1 < tat < MMP2

PSMA4 < tat < MMP2
PSMA6 < tat < MMP2
PSMA6 < TIMP2 < MMP2

PSMB2 < tat < MMP2
PSMB3 < tat < MMP2
PSMA2 < tat < MMP2

PSMD12 < tat < MMP2
PSMD11 < tat < MMP2
PSMA3 < tat < MMP2

PSMA1 < tat < MMP2
PSMB6 < tat < MMP2
PSMA7 < tat < MMP2

PSMB5 < tat < MMP2
19
PSMD14
PSMA1
PSMA2
PSMA3

PSMA4
PSMA5
PSMA6
PSMA7

PSMB1
PSMB2
PSMB3
PSMB4

PSMB5
PSMB6
PSMB7
PSMD3

PSMD4
PSMD11
PSMD12
RPN1

RPN2
UBA1
UBE2A
UBE3A
24
Biocarta id :
  hcpathway
antigen processing and presentation 220.00
N/A
N/A
PSMB9 < tat < MMP2
PSMB8 < tat < MMP2
KLK3 < A2M < MMP2

KLK3 < IGFBP3 < MMP2
PSMB6 < tat < MMP2
PSMB5 < tat < MMP2

HLA-A < env < MMP2
HLA-DRA < tat < MMP2
HLA-DRA < env < MMP2

HLA-DRB1 < tat < MMP2
HLA-DRB1 < env < MMP2
11
HLA-A
HLA-DRA
HLA-DRB1
KLK3

B2M
PSMB5
PSMB6
PSMB8

PSMB9
TAP1
TAP2
CD74
12
Reactome id :
  277
Lectin pathway of complement activation - (Reactome
via Pathway Interaction Database)
20.00
N/A
N/A
MBL2 < env < MMP2
1
MASP1
MASP2
MBL2
3
PA164713560 il22 soluble receptor signaling pathway - (BioCarta
via Pathway Interaction Database)
20.00
N/A
N/A
STAT3 < HSP90AA1 < MMP2
1
IL10RA
IL22
IL22RA1
IL22RA2

JAK1
SOCS3
STAT3
TYK2
8
*Total number of Query Gene in Pathway     **Total number of Genes in Pathway