MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)



Official Symbol  MMP2provided by HGNC
Official Full Name  matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)provided by HGNC
Primary source  HGNC:7166
See related  Ensembl:ENSG00000087245;HPRD:00386;MIM:120360;Vega:OTTHUMG00000133202
Gene type  protein coding
RefSeq status  REVIEWED
Organism  Homo sapiens
Lineage  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as  CLG4 MONA; CLG4A; TBE-1; MMP-II
Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]..
Source Institution: National Center for Biotechnology Information
Source Author:
Original Link: http://www.ncbi.nlm.nih.gov/gene/4313