KIF5B-RET fusions in lung adenocarcinoma


Nature Medicine
 
(2012)

We identified in-frame fusion transcripts of KIF5B (the kinesin family 5B gene) and the RET oncogene, which are present in 1–2% of lung adenocarcinomas (LADCs) from people from Japan and the United States, using whole-transcriptome sequencing. The KIF5B-RET fusion leads to aberrant activation of RET kinase and is considered to be a new driver mutation of LADC because it segregates from mutations or fusions in EGFRKRASHER2 and ALK, and a RET tyrosine kinase inhibitor, vandetanib, suppresses the fusion-induced anchorage-independent growth activity of NIH3T3 cells.

Source Institution: National Cancer Center Research Institute, Japan
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Original Link: http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.2644.html